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Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis  D.D. Kumarasinghe,

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Presentation on theme: "Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis  D.D. Kumarasinghe,"— Presentation transcript:

1 Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis  D.D. Kumarasinghe, E. Perilli, H. Tsangari, L. Truong, J.S. Kuliwaba, B. Hopwood, G.J. Atkins, N.L. Fazzalari  Osteoarthritis and Cartilage  Volume 18, Issue 10, Pages (October 2010) DOI: /j.joca Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

2 Fig. 1 a) Photomicrograph of a 5μm section of trabecular bone section from the IT region of the proximal femur of a primary hip OA case (×2.5 magnification). (b) Photomicrograph of a 5μm section of trabecular bone section from the IT region of the proximal femur of a CTL case (×2.5 magnification). Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

3 Fig. 2 a) TWIST1 mRNA expression from the IT region of the proximal femur of OA patients (n=23) and CTL cases (n=21), data are expressed as non-parametric median and inter-quartile range (P=0.002). (b) Percent bone volume fraction (BV/TV) from the IT region of the proximal femur of OA patients and CTL cases, data are expressed as median and inter-quartile range (P=0.009). (c) Significant positive correlation with 95% confidence interval (r=+0.567) between TWIST1 and BV/TV from the IT region of the proximal femur in CTL (P=0.043), no significant correlation was observed in OA. Osteoarthritis and Cartilage  , DOI: ( /j.joca ) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions


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