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A clinicopathologic study of immunoglobulin G4-related disease of the femoral and popliteal arteries in the spectrum of immunoglobulin G4-related periarteritis 

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Presentation on theme: "A clinicopathologic study of immunoglobulin G4-related disease of the femoral and popliteal arteries in the spectrum of immunoglobulin G4-related periarteritis "— Presentation transcript:

1 A clinicopathologic study of immunoglobulin G4-related disease of the femoral and popliteal arteries in the spectrum of immunoglobulin G4-related periarteritis  Satomi Kasashima, MD, PhD, Atsuhiro Kawashima, MD, PhD, Masamitsu Endo, MD, PhD, Yasushi Matsumoto, MD, PhD, Fuminori Kasashima, MD, PhD, Yoh Zen, MD, PhD, Yasuni Nakanuma, MD, PhD  Journal of Vascular Surgery  Volume 57, Issue 3, Pages (March 2013) DOI: /j.jvs Copyright © 2013 Society for Vascular Surgery Terms and Conditions

2 Fig 1 a, A three-dimensional coronal reconstruction of an immunoglobulin G4 (IgG4)-related peripheral aneurysm of the deep left femoral artery having a saccular shape (patient 3, arrow). This patient also had aneurysms of the abdominal aorta and left iliac artery. b, Macroscopic findings of this saccular aneurysm (patient 3). The arrow is pointing to the inflow artery (aneurysmal neck). The aneurysm wall showed irregular thickness with calcification. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Histopathologic features of immunoglobulin G4 (IgG4)-related peripheral aneurysms of the right popliteal artery (patient 2). a and b, Thickened fibrotic media is seen extending to the adventitia, showing loss of elastic fibers and muscles of the media and inflammatory cell infiltration mainly in the adventitia of the arterial wall. Fibrous tissue extends into adjacent adventitial fat (a, hematoxylin and eosin; b, elastica van Gieson; both images, original magnification, ×20 in almost the same field). c, Numerous IgG4-immunopositive plasma cells were detected in the adventitia of the IgG4-related peripheral arterial aneurysm (original magnification, ×200). d, Perineural infiltration of lymphoplasma cells (original magnification, ×200). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2013 Society for Vascular Surgery Terms and Conditions


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