1. Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2016.211
Figure 3 Tumour-cell division coexists with apoptosis in stable tumours
Figure 3 | Tumour-cell division coexists with apoptosis in stable tumours. a | Immunohistochemical assays of slides containing sequential slices of tumours from mice that remained stable after radiotherapy, stained with anti-Ki67, anti-TUNEL (scale bar: 50 μm), and anti-CD8 antibodies; Ki67, TUNEL, and CD8 are markers of cell proliferation, apoptosis, and cytotoxic T cells, respectively. Analysis of the stain patterns reveals that apoptotic cells are colocalized with CD8 T cells, whereas proliferative cells are generally located at distinct sites. b | Quantification of the relative intensity of TUNEL staining in areas of the tumour containing CD8+ and Ki67+ cells. Three or four high-power fields were counted per mouse (n = 3). **P =
Weichselbaum, R. R. et al. (2017) Radiotherapy and immunotherapy: a beneficial liaison?
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