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Introduction to IV Admixture and Aseptic Technique Pharmacy 721 January 23-27, 2006.

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Presentation on theme: "Introduction to IV Admixture and Aseptic Technique Pharmacy 721 January 23-27, 2006."— Presentation transcript:

1 Introduction to IV Admixture and Aseptic Technique Pharmacy 721 January 23-27, 2006

2 Objectives Background and Definitions Background and Definitions Equipment Equipment USP 797 USP 797 Technique Technique

3 Background Parenteral: injected through skin or other external boundary tissue, alongside of small intestine Parenteral: injected through skin or other external boundary tissue, alongside of small intestine Uses: Uses: NPO – nothing by mouth NPO – nothing by mouth Unstable in GI, 1 st pass metabolism Unstable in GI, 1 st pass metabolism Immediate action needed Immediate action needed Delivery to specific site Delivery to specific site Depot form Depot form

4 Definitions LVP-large volume parenteral (>100 ml) LVP-large volume parenteral (>100 ml) piggy back – smaller volume (may be up to 250 ml) piggy back – smaller volume (may be up to 250 ml) D5W (5% dextrose in water) D5W (5% dextrose in water) NS (normal saline) 0.9%NaCl NS (normal saline) 0.9%NaCl Compounded Sterile Preparation (CSP) Compounded Sterile Preparation (CSP) Continuous infusion vs. intermittent dosing Continuous infusion vs. intermittent dosing

5 Definitions HEPA filter- High Efficiency Particulate Air HEPA filter- High Efficiency Particulate Air 0.3 micron, 99.97% 0.3 micron, 99.97% ISO: International Organization for Standardization ISO: International Organization for Standardization ISO 5: Clean room standards based on particles for cubic meter by particle size ISO 5: Clean room standards based on particles for cubic meter by particle size Class 100: number of particles 5 μm per cubic foot Class 100: number of particles 5 μm per cubic foot

6 Hood types Horizontal Laminar Airflow Workbench Horizontal Laminar Airflow Workbench

7 Hood Types Vertical Laminar Airflow Workbench (Biosafety) Vertical Laminar Airflow Workbench (Biosafety)

8 Hood Types Barrier Isolator Barrier Isolator

9 USP 797 Risk Levels High (3) High (3) Nonsterile ingredients Nonsterile ingredients { "@context": "http://schema.org", "@type": "ImageObject", "contentUrl": "http://images.slideplayer.com/5/1525437/slides/slide_9.jpg", "name": "USP 797 Risk Levels High (3) High (3) Nonsterile ingredients Nonsterile ingredients

10 Clean room Video Video

11 Syringes and Needles Parts of syringe (32.12) Parts of syringe (32.12) Barrel Barrel Plunger Plunger Tip Tip Parts of needle (32.12) Parts of needle (32.12) Bevel Bevel Shaft Shaft Hub Hub

12 Injection technique Critical sites Critical sites Swabbing Swabbing Bevel up, angle Bevel up, angle Equalize pressure Equalize pressure

13 IV Preparation Preparation Preparation Calculations Calculations Assembly Assembly Cleaning Cleaning Inspection Inspection Expiration dates Expiration dates Quality Quality Manipulation Manipulation Inspection Inspection Quality Quality

14 References and Resources USP, Proposed Revisions to USP Chapter http://www.usp.org/healthcareInfo/pharmInfo/revisions797.html USP, Proposed Revisions to USP Chapter http://www.usp.org/healthcareInfo/pharmInfo/revisions797.html http://www.usp.org/healthcareInfo/pharmInfo/revisions797.html ASHP Self Assessment Tool for Compounding Sterile Preparations http://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Ass essment.pdf ASHP Self Assessment Tool for Compounding Sterile Preparations http://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Ass essment.pdf http://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Ass essment.pdf http://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Ass essment.pdf Ockerman AV, U.S. Pharmacist, Compounded Sterile Preparations: An Overview of the New Standards USP http://www.uspharmacist.com/index.asp?show=article&page=8_12 52.htm Ockerman AV, U.S. Pharmacist, Compounded Sterile Preparations: An Overview of the New Standards USP http://www.uspharmacist.com/index.asp?show=article&page=8_12 52.htm http://www.uspharmacist.com/index.asp?show=article&page=8_12 52.htm http://www.uspharmacist.com/index.asp?show=article&page=8_12 52.htm ASHP Guidelines on Quality Assurance for Pharmacy-Prepared Sterile Products, Am J Health-Syst Pharm, 2000;57:1150-69 ASHP Guidelines on Quality Assurance for Pharmacy-Prepared Sterile Products, Am J Health-Syst Pharm, 2000;57:1150-69


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