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Graham Watt Jackie Ankomah Dilmini Peiris Bryan Cawthorn.

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Presentation on theme: "Graham Watt Jackie Ankomah Dilmini Peiris Bryan Cawthorn."— Presentation transcript:

1 Graham Watt Jackie Ankomah Dilmini Peiris Bryan Cawthorn

2 Background of centrifugation – purpose Centrifuge designs – different requirements Disc stack centrifuge technology Our centrifuge – process Design choice and sizing Costing analysis

3 Downstream processing is a major consideration in industry - separation of products/byproducts/wastes -separation of multiple phases, liquids/solids Specific to our application, removal of biomass from production stream -can be achieved through application of centripetal force -similar principles to use of settling tank, accelerated

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5 Filters – low solids concentration Disc stack centrifuge – increasing concentration Decanter centrifuge – higher concentration

6 Courtesy Alfa-Laval, 2008 Our Process - 1% solids ** - 1micron diameter

7 Subjecting the material to high centrifugal forces denser solids outwards -causes separation of solid and liquids phases -allows removal of solids manually, intermittently, or continuously Courtesy Alfa-Laval, 2008

8 Centrifugation systems are very sensitive to changes in material composition - liquid media viscosity will impact settling rate (Stokes Law) - liquid flowrate through centrifuge - particle size (flocculation interactions) - cell integrity - rate limiting steps in process – fermentation of 12 days

9 Recommendation courtesy Stanley Foster, Alfa Laval Alfa Laval Culturefuge Designed to limit cell disruption - Hermetic seal preventing air/liquid interface - Allows for necessary throughputs Courtesy Elsevier, 2008

10 Liquid Viscosity – 1.5cP Particle Diameter – 1micron Throughput – 63.7L/h Outer disk radius- 0.75m Inner disk radius- 0.5m Number of disks- 10 Centrifugation time- 10 days Cost estimation- $80,000

11 Courtesy Alfa-Laval, 2008

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