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Volume 19, Issue 3, Pages 193-203 (June 2012)
Expression of cardiac GATA4 and downstream genes after exercise training in the db/db mouse Tom L. Broderick, Cassandra R. Parrott, Donghao Wang, Marek Jankowski, Jolanta Gutkowska Pathophysiology Volume 19, Issue 3, Pages (June 2012) DOI: /j.pathophys Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 1 Physical characteristics of control mice, db/db mice, and db/db mice after exercise training on body weight (A), blood glucose (B), heart weight (C), and the heart weight-to-body weight ratio (D). Values are expressed as mean±SEM for 10–12 mice in each group. CN, control mice; DS, diabetic sedentary mice; DT, diabetic trained mice. *p<0.05, **p<0.01, ***p<0.001. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 2 Expression of IRAP mRNA (A) and protein (B) hearts from in control mice, db/db mice, and db/db mice subjected to exercise training. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; DS, diabetic sedentary mice; DT, diabetic trained mice. **p<0.01. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 3 Cardiac GATA4 mRNA expression (A) and protein expression (B) in control and db/db hearts. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; DS, diabetic sedentary mice; DT, diabetic trained mice. *p<0.05, ***p<0.001. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 4 Cardiac oxytocin mRNA expression (A), oxytocin receptor mRNA expression (B) and oxytocin receptor protein expression (C) in control and db/db hearts. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; DS, diabetic sedentary mice; DT, diabetic trained mice. *p<0.05, **p<0.01, ***p<0.001. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 5 Cardiac ANP mRNA expression (A) and BNP mRNA expression (B) in control and db/db hearts. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; DS, diabetic sedentary mice; DT, diabetic trained mice. *p<0.05, ***p<0.001. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 6 Cardiac α-MHC mRNA expression (A), β-MHC mRNA expression (B) and the β/α mRNA MHC ratio (C) in control and db/db hearts. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; CT, control trained mice; DS, diabetic sedentary mice; DT, diabetic trained mice. *p<0.05, **p<0.01. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 7 Cardiac eNOS mRNA expression (A) and eNOS protein expression (B) in control and db/db hearts. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; DS, diabetic sedentary mice; DT, diabetic trained mice. *p<0.05, ***p<0.001. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 8 Cardiac VEGF mRNA (A) and protein (B) expression, and HIF-1 mRNA (C) and protein (D) expression in control and db/db hearts. Values are expressed as mean±SEM obtained from 5 to 6 hearts in each group. CN, control mice; CT, control trained mice; DS, diabetic sedentary mice; DT, diabetic trained mice. *p<0.05, **p<0.01. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 9 Cardiac NAB-1 mRNA expression (A) and NAB-1 protein expression (B) in control and db/db hearts. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; DS, diabetic sedentary mice; DT, diabetic trained mice. ***p<0.001. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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Fig. 10 Cardiac HSP70 mRNA expression (A) and HSP70 protein expression (B) in control and db/db hearts. Values are expressed as mean±SEM obtained from 2 separate experiments each performed with 5 hearts. CN, control mice; CT, control trained mice; DS, diabetic sedentary mice; DT, diabetic trained mice. **p<0.01, ***p<0.001. Pathophysiology , DOI: ( /j.pathophys ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions
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