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A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients.

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Presentation on theme: "A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients."— Presentation transcript:

1 A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non- small Cell Lung Cancer  Andrew Weickhardt, MBBS, DMedSc, Robert Doebele, MD, PhD, Ana Oton, MD, Janice Lettieri, BSN, DeLee Maxson, BS, Michele Reynolds, BS, Amy Brown, PhD, Mary K. Jackson, AD, Grace Dy, MD, Araba Adjei, PhD, Gerald Fetterly, PhD, Xian Lu, MSc, Wilbur Franklin, MD, Marileila Varella-Garcia, PhD, Fred R. Hirsch, MD, PhD, Murry W. Wynes, PhD, Hagop Youssoufian, MD, Alex Adjei, MD, PhD, D. Ross Camidge, MD, PhD  Journal of Thoracic Oncology  Volume 7, Issue 2, Pages (February 2012) DOI: /JTO.0b013e31823c5b11 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Dose cohorts in the phase I trial.
Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31823c5b11) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 A, Progression-free survival and (B) waterfall plot of best response. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31823c5b11) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 A, Progression-free survival and (B) dose intensity of patients by baseline free IGF-1 quartiles. The middle line of the box plots represents the median. The box represents the upper and lower quartiles, and the line extends from the lowest to the highest PFS values. †Includes two EGFR-MT patients and one EGFR unknown patient. IGF, insulin-like growth factor; PFS, progression-free survival; EGFR-MT, EGFR mutation. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e31823c5b11) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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