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Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,

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Presentation on theme: "Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer  Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD,"— Presentation transcript:

1 Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer 
Mian Xie, MD, PhD, Li Zhang, MD, Chao-Sheng He, MD, Jin-Hui Hou, MD, Su-Xia Lin, MD, PhD, Zhi-Huang Hu, MD, Fei Xu, MD, Hong- Yun Zhao, MD, PhD  Journal of Thoracic Oncology  Volume 7, Issue 5, Pages (May 2012) DOI: /JTO.0b013e b Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Western blot analysis of TAZ expression in normal human bronchial epithelial (HBE) and NSCLC cell lines. Cell lysates extracted from these cell lines were subjected to Western blot using anti-TAZ and anti-β-actin antibodies. The levels of β-actin were used as internal protein loading controls. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e b) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Immunohistochemistry staining of TAZ in NSCLC. TAZ positive expression in both nucleus and cytoplasm of lung adenocarcinoma (A). TAZ positive expression in lung squamous carcinoma, staining in both cytoplasm and nucleus of tumor cells (B). Negative TAZ expression in lung adenocarcinoma (C). Negative expression in normal lung tissue (D). Original magnification, ×200. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e b) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Overall survival curves with TAZ expression results in the entire population (A), in stage I NSCLC patients (B), and in stage II/ III NSCLC patients (C). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e b) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

5 FIGURE 4 Disease-free survival curves with TAZ expression results in the entire population (A), in stage I NSCLC patients (B), and in stage II/ III NSCLC patients (C). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e b) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

6 FIGURE 5 Disease-free survival curve (A) and overall survival (B) among patients with TAZ positive expression. Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e b) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

7 FIGURE 6 Kaplan-Meier estimates of overall survival between adjuvant chemotherapy group and observation group among patients with TAZ positive expression (A) or those without TAZ expression (B). Journal of Thoracic Oncology 2012 7, DOI: ( /JTO.0b013e b) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

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