1. Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians 
Lucia Elena Alvarado Arnez, BS, Evaristo N. Venegas, MSc, Carole Ober, PhD, Emma E. Thompson, PhD 
Journal of Allergy and Clinical Immunology 
Volume 127, Issue 1, Pages e3 (January 2011)
DOI: /j.jaci
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Visual representation of haplotypes at the IL4 locus. Haplotypes are sorted by the derived (clade A) or ancestral (clade B) allele at −590C/T (designated by ∗). Three exonic SNPs are indicated by +. White squares correspond to ancestral alleles and black squares to derived alleles. A schematic of the IL4 gene is shown at the bottom of the figure; filled rectangles show exons (drawn to scale).
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3. Chromatograms of 12 singleton variants not previously reported or verified by multiple sequence reads. Positions relative to AF in Genbank are followed by rs numbers above each image. Sites are indicated by vertical white lines. Traces containing polymorphic sites appear on the bottom and traces containing the reference sequence appear on top.
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4. Neighbor joining tree (constructed by using Network; http://www
Neighbor joining tree (constructed by using Network; of haplotypes in Bolivians with the chimpanzee sequence as the ancestral sequence. Each circle represents a different haplotype, with the size of the circle proportional to the frequency of that haplotype in the combined sample. The proportions of each haplotype present in the infected subject and uninfected control groups are shown as black and gray shading, respectively, in each circle. Polymorphic positions are indicated along the branches. SNPs whose frequencies differ between case and control groups at P <.05 are shown in black boxes.
Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions