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Natsuko Tokushige, Ph. D. , Robert Markham, Ph. D. , Peter Russell, M

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Presentation on theme: "Natsuko Tokushige, Ph. D. , Robert Markham, Ph. D. , Peter Russell, M"— Presentation transcript:

1 Effect of progestogens and combined oral contraceptives on nerve fibers in peritoneal endometriosis 
Natsuko Tokushige, Ph.D., Robert Markham, Ph.D., Peter Russell, M.D., Ian S. Fraser, M.D.  Fertility and Sterility  Volume 92, Issue 4, Pages (October 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Nerve fibers in peritoneal endometriotic lesions treated with progestogens. (A) A peritoneal lesion from a treated patient stained for protein gene product 9.5 (PGP9.5). Black arrows denote nerve fibers stained for PGP9.5, and a yellow arrow denotes an endometriotic gland. (B) A peritoneal lesion stained for neurofilament (NF). Arrow denotes myelinated A-delta nerve fibers stained for NF. (C) A peritoneal lesion stained for TH. Arrow denotes adrenergic nerve fibers stained for tyrosine hydroxylase (TH). (D) A peritoneal lesion stained for vesicular acetylcholine transporter (VAChT). Arrows denote cholinergic nerve fibers stained for VAChT. (E) A peritoneal lesion stained for vasoactive intestinal polypeptide (VIP). Arrow denotes sensory C nerve fibers stained for VIP. (F) A peritoneal lesion stained for neuropeptide Y (NPY). Arrow denotes sensory C nerve fibers stained for NPY. (G) A peritoneal lesion stained for CGRP. Arrow denotes a very small number of sensory C nerve fibers stained for calcitonin gene related peptide (CGRP). (H) A peritoneal lesion stained for substance P (SP). There was no positive SP staining in this progestogen-treated woman. (A: magnification ×200. B–H: magnification ×200.) Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Peritoneal endometriotic lesions from women who were receiving progestogens. (A) A peritoneal lesion strongly stained for nerve growth factor (NGF) throughout the stroma (magnification ×100). (B) A peritoneal lesion strongly stained for nerve growth factor receptor p75 (NGFRp75) throughout the stroma (magnification ×200). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions


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