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One Niche to Rule Both Maintenance and Loss of Stemness in HSCs

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Presentation on theme: "One Niche to Rule Both Maintenance and Loss of Stemness in HSCs"— Presentation transcript:

1 One Niche to Rule Both Maintenance and Loss of Stemness in HSCs
Motonari Kondo  Immunity  Volume 45, Issue 6, Pages (December 2016) DOI: /j.immuni Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 BM Cells Produce IL-7
Mesenchymal stem/progenitor cells, CAR cells, epithelial cells, all of which are HSC niche-forming cells, produce IL-7. HSCs, MPPs, and CLPs are located in close proximity to IL-7+ BM cells in a CXCL12-CXCR4-dependent manner. ProB cells expand in response to IL-7 produced by various IL-7+ BM cells. Immunity  , DOI: ( /j.immuni ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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