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Insulin resistance and inflammation are a cause of hyperglycemia after pediatric cardiopulmonary bypass surgery  Alejandro A. Floh, MD, Cedric Manlhiot,

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Presentation on theme: "Insulin resistance and inflammation are a cause of hyperglycemia after pediatric cardiopulmonary bypass surgery  Alejandro A. Floh, MD, Cedric Manlhiot,"— Presentation transcript:

1 Insulin resistance and inflammation are a cause of hyperglycemia after pediatric cardiopulmonary bypass surgery  Alejandro A. Floh, MD, Cedric Manlhiot, BS, Andrew N. Redington, MBBS, MD, Brian W. McCrindle, MD, MPH, Nadia A. Clarizia, BS, Christopher A. Caldarone, MD, Steven M. Schwartz, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 150, Issue 3, Pages e1 (September 2015) DOI: /j.jtcvs Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 The incidence of postoperative hyperglycemia at various time points during the 48 hours immediately after CPB: moderate hyperglycemia (>180 mmol/L; black); severe hyperglycemia (>270 mmol/L; gray). CPB, Cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Glucose-to-insulin ratio at various time points during the 48 hours immediately after CPB is shown, from linear regression models adjusted for repeated measures over time, and variable sampling through a compound symmetry covariance structure. Circles represent estimated average values; bars represent SDs. CPB, Cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Cytokine concentrations at various time points during the first 48 hours immediately after CPB. Plasma IL-6 (blue) and plasma TNF-α (red) concentrations are from linear regression models adjusted for repeated measures over time, and variable sampling through a compound symmetry covariance structure. Squares and circles represent estimated average values; bars represent SDs. Offset of times 0 (immediately after end of CPB) and 48 hours are for visual purposes only; data were collected at the same time points. IL, Interleukin; TNF, tumor necrosis factor; CPB, cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E1 Scatterplot comparing log-transformed plasma glucose to log-transformed plasma insulin concentrations (r2 = 0.18; P < .001). The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

6 Glucose-to-insulin ratio at various time points during the 48 hours immediately after CPB.
The Journal of Thoracic and Cardiovascular Surgery  , e1DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions


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