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CorMatrix Extracellular Matrix Used for Valve Repair in the Adult: Is There De Novo Valvular Tissue Seen?  Adriana Luk, MD, FRCPC, Vivek Rao, MD, FRCSC,

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Presentation on theme: "CorMatrix Extracellular Matrix Used for Valve Repair in the Adult: Is There De Novo Valvular Tissue Seen?  Adriana Luk, MD, FRCPC, Vivek Rao, MD, FRCSC,"— Presentation transcript:

1 CorMatrix Extracellular Matrix Used for Valve Repair in the Adult: Is There De Novo Valvular Tissue Seen?  Adriana Luk, MD, FRCPC, Vivek Rao, MD, FRCSC, Robert J. Cusimano, MD, FRCSC, Tirone E. David, MD, FRCSC, Jagdish Butany, MS, FRCPC  The Annals of Thoracic Surgery  Volume 99, Issue 6, Pages (June 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Mitral valve tissue explanted from case 1 (10 months). In (A), there is a host response to the CorMatrix (asterisk) on both surfaces (original magnification × 1.2, stain Movat pentachrome). Fibroblasts can be seen penetrating within the biomaterial (B). Endothelial cells (C), macrophages (D) and leukocytes (E) are seen at the junction of native tissue and CorMatrix. Original magnification ×20 (B, Vimentin stain; C, CD 31; D, CD 68; and E, CD 45). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Mitral valve tissue explanted from case 2 (18 months). In (A), the trilaminar appearance can be seen (asterisk). Calcification (arrowheads) can be seen at the anastomosis site, without inflammatory cells seen (original magnification ×1.25, stain: Movat pentachrome). In (B), the material appears more compact than tissues explanted at 10 months. There are more fibroblasts seen (original magnification ×20, stain Movat pentachrome). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions


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