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Interleukin-18: The Bouncer at the Mucosal Bar

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Presentation on theme: "Interleukin-18: The Bouncer at the Mucosal Bar"— Presentation transcript:

1 Interleukin-18: The Bouncer at the Mucosal Bar
Timothy W. Hand  Cell  Volume 163, Issue 6, Pages (December 2015) DOI: /j.cell Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Role of Inflammasome and IL-18 in Barrier Function
(A) At steady state, a healthy bacterial microbiota produces metabolites, such as taurine, that support inflammasome-mediated production of IL-18 and anti-microbial proteins in the colon that promote microbial diversity and prevent commensal dysbiosis. (B) A dysbiotic microbiota is characterized by different metabolites, such as spermine, that inhibit the inflammasome and inhibit anti-microbial protein production, allowing for its invasive character. During inflammation-induced colitis, IL-18 prevents the development of goblet cells from uncommitted precursors, significantly reducing mucus production and intestinal barrier function. Cell  , DOI: ( /j.cell ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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