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Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia  Enyi Shi, MD, PhD, Xiaojing.

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Presentation on theme: "Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia  Enyi Shi, MD, PhD, Xiaojing."— Presentation transcript:

1 Controlled low-pressure perfusion at the beginning of reperfusion attenuates neurologic injury after spinal cord ischemia  Enyi Shi, MD, PhD, Xiaojing Jiang, MD, Teruhisa Kazui, MD, PhD, Naoki Washiyama, MD, PhD, Katsushi Yamashita, MD, PhD, Hitoshi Terada, MD, PhD, Abul Hasan Muhammad Bashar, MBBS, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 133, Issue 4, Pages (April 2007) DOI: /j.jtcvs Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Mean distal aortic pressure. NR, Normal reperfusion group; LR, low-pressure reperfusion group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Neurologic function assessed with Tarlov score at 1, 2, 7, and 14 days after ischemia. Individual rabbits (triangles). NR, Normal reperfusion group; LR, low-pressure reperfusion group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 MDA levels of lumbar spinal cords 24 hours after reperfusion. NR, Normal reperfusion group; LR, low-pressure reperfusion group; MDA, Malondialdehyde. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Histologic assessment of the spinal cord 14 days after transient ischemia. A, Representative sections of lumbar spinal cords stained with hematoxylin-eosin (magnification 100×). B, Number of large motor neurons in the ventral gray matter. NR, Normal reperfusion group; LR, low-pressure reperfusion group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 Vacuolation in white matter of lumbar spinal cords. A, Representative photomicrographs of the ventrolateral white matter in hematoxylin-eosin–stained sections (magnification 200×). B, Percentage of vacuolation area in white matter. NR, Normal reperfusion group; LR, low-pressure reperfusion group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

7 Figure 6 Expression of APP in white matter of lumbar spinal cord. A, Photomicrographs of the immunohistochemical staining for APP in the ventrolateral white matter (magnification 200×). B, APP scores of the 2 groups. NR, Normal reperfusion group; LR, low-pressure reperfusion group; APP, amyloid precursor protein. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

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