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Health Effects Division Office of Pesticide Programs Dietary Exposure Assessment Activities at U.S. EPA's Office Pesticide Programs Interagency Risk Assessment.

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Presentation on theme: "Health Effects Division Office of Pesticide Programs Dietary Exposure Assessment Activities at U.S. EPA's Office Pesticide Programs Interagency Risk Assessment."— Presentation transcript:

1 Health Effects Division Office of Pesticide Programs Dietary Exposure Assessment Activities at U.S. EPA's Office Pesticide Programs Interagency Risk Assessment Consortium Workshop on Chemical Food Safety Risk Assessment FDA – Center for Food Safety and Applied Nutrition Aaron Niman LT, USPHS Office of Pesticide Programs US Environmental Protection Agency June 14, 2012 Health Effects Division Office of Pesticide Programs

2 Health Effects Division Office of Pesticide Programs Overview 1.U.S. EPAs Office of Pesticide Programs (OPP) 2.OPPs dietary exposure assessment methodology 3.Dietary Exposure Assessment Resources – Food Commodity Intake Database (FCID) – JIFSAN Foodrisk.org Web Application – Dietary Exposure Evaluation Model (DEEM) – Stochastic Human Exposure and Dose Simulation (SHEDS) Model 2

3 Health Effects Division Office of Pesticide Programs EPAs Office of Pesticide Programs Registers pesticides for agricultural, residential, and public health applications Evaluates safety of pesticides by assessing exposure and associated risks Establishes legal limits (aka tolerances) for pesticides on agricultural commodities 3 Antimicrobials Health Effects Environmental Fate & Effects Biopesticides & Pollution Prevention Biological & Economic Analysis Registration Pesticide Re-Evaluation Field & External Affairs IT Office Director

4 Health Effects Division Office of Pesticide Programs Dietary Exposure Assessment Approach Evaluate food consumption patterns and residue concentrations that lead to highest potential for exposure Assessments range from simple to complex, but based on same general exposure algorithm Tiering process used to refine exposure assessment to reflect more realistic assumptions 4 X = ResidueConsumption Dietary Exposure

5 Health Effects Division Office of Pesticide Programs Dietary Exposure Modeling Exposure assessment models based on nationally-representative monitoring surveys Key data surveys and databases: – USDAs Pesticide Data Program (PDP) Nationally representative commodity residue sampling program – Continuing Survey of Food Intake by Individuals (CSFII) (1994-96/1998) NHANES What We Eat In America (WWEIA) Nationally representative food consumption surveys – U.S. EPAs Food Commodity Intake Database (FCID) Recipe database that links WWEIA foods to PDP residue data 5

6 Health Effects Division Office of Pesticide Programs Dietary Exposure Modeling Food Consumption (WWEIA) Food Recipe Database (FCID) Raw Ingredient Consumption Ingredient Pesticide Residue (USDA/PDP) + = Dietary Exposure 6 Risk Acceptable Level aPAD, cPAD, etc.

7 Health Effects Division Office of Pesticide Programs Modeling tools rely on probabilistic techniques (Monte-Carlo) to evaluate exposure Techniques are routinely applied by OPP for virtually all of its pesticide risk assessments Allow the Agency to characterize and quantify the variability in dietary exposure across various subgroups of interest 7 Dietary Exposure Modeling X= All Residue Values All Consumption Values Range of Dietary Exposures

8 Health Effects Division Office of Pesticide Programs 8 SHEDS-Multimedia DEEM-FCID/Calendex Dietary Exposure Modeling

9 Health Effects Division Office of Pesticide Programs Dietary Resources Food Commodity Intake Database Recipe database used by EPA/OPP in exposure assessment models Developed using CSFII, 1994-96, 1998 Updated for NHANES-WWEIA, 2003-08 Foodrisk.org Web Application – FCID recipe search tool – Links to NHANES-WWEIA – Population-based consumption estimates Dietary Exposure Evaluation Model (DEEM) – Dietary exposure assessment mode – Now free and publically available – Utilizes NHANES WWEIA 2003-08 survey data Stochastic Human Exposure and Dose Simulation (SHEDS) Model – Developed by EPAs Office of Research and Development – Simulates aggregate and cumulative dietary exposure 9

10 Health Effects Division Office of Pesticide Programs Food Commodity Intake Database (FCID) Both CSFII and WWEIA Captures dietary recall data on foods as reported eaten Examples: 1 slice apple pie, 1 Big Mac, 1 slice Cheese Pizza (1/8 of 12 pie) Pesticide residue information and regulatory focus is on a food commodity basis Therefore, estimating dietary exposure requires converting data on foods as eaten to food commodities (e.g, tomato sauce, wheat flour, apples, soybean oil, beef, milk, etc.) 10

11 Health Effects Division Office of Pesticide Programs Food Commodity Intake Database (FCID) Translates foods as reported eaten to raw agricultural commodities using U.S. EPA food vocabulary – Developed in collaboration with USDA s Agricultural Research Service – Originally based on: CSFII 1994-96/1998 USDAs Food and Nutrient Database for Dietary Studies (FNDDS) Converts more than 5,000 food codes into recipes containing roughly 540 difference food commodities 11

12 Health Effects Division Office of Pesticide Programs Food Commodity Intake Database (FCID) Also includes additional information on food commodities (used subsequently in exposure modeling) – Cooked Status (Yes, No) – Food Form (Fresh, frozen, etc.) – Cooking Method (Baked, boiled, etc.) 12

13 Health Effects Division Office of Pesticide Programs Food Commodity Intake Database: Example 13

14 Health Effects Division Office of Pesticide Programs Updating FCID: WWEIA 2003-2008 New Recipe Formation – New recipes were needed for foods that were not included in earlier versions of FCID. – Some of these new foods were easily matched to an already existing recipe for a similar food that was in the CSFII-FCID database, with little or no modification necessary. – Other foods required generating a recipe from scratch, or using an already existing recipe but applying significant alterations to their ingredients. 14

15 Health Effects Division Office of Pesticide Programs FCID Accessibility Developed database and user interface in MS Access Web application with USDAs Food Safety Inspection Service and U-Marylands Joint Institute of Food Safety and Applied Nutrition (JIFSAN) Functionality – Improve transparency of coded fields – Make recipes fully searchable – Make recipe format more user-friendly – Enable users to estimate consumption of food commodities Weighted mean and percentile calculations 15 http://fcid.foodrisk.org/

16 Health Effects Division Office of Pesticide Programs Dietary Exposure Evaluation Model (DEEM) EPA/OPP has acquired DEEM license and made freely available to the public – Improve accessibility – Increase transparency of EPA/OPP regulatory decisions DEEM Updates and Release – Incorporates WWEIA 2003-08 consumption data – Addressed stakeholder feedback from Fall 2011 beta testing – Enables eating occasion analysis 16 http://www.epa.gov/pesticides/science/deem/

17 Health Effects Division Office of Pesticide Programs DEEM – User Interface 17

18 Health Effects Division Office of Pesticide Programs DEEM – User Interface 18

19 Health Effects Division Office of Pesticide Programs DEEM – User Interface 19

20 Health Effects Division Office of Pesticide Programs SHEDS-Multimedia State-of-the-science model developed by EPAs Office of Research and Development Enables longitudinal assessment of exposure from multimedia sources SHEDS-Residential v.4: Residential model that can simulate cumulative or aggregate residential exposures over time via multiple routes of exposure for different types of chemicals and scenarios. SHEDS-Dietary v.1: Dietary model that can simulate individual exposures to chemicals in food and drinking water over different time periods Collaborated closely with EPAs Office of Pesticide Programs with extensive peer-review by the FIFRA Scientific Advisory Panel 20 http://www.epa.gov/heasd/products/sheds_multimedia/sheds_mm.html

21 Health Effects Division Office of Pesticide Programs SHEDS-Dietary v.1: Longitudinal Analysis 21

22 Health Effects Division Office of Pesticide Programs SHEDS-Dietary v.1: Uncertainty Analysis 22

23 Health Effects Division Office of Pesticide Programs Whats Next FCID Recipe Database – FCID 2003-06 available through foodrisk.org – Working to finalize 2003-08 recipe CR-ROM and make available through JIFSAN foodrisk.org website DEEM-WWEIA 2003-08 – Available through EPA/OPP website – Performing model-to-model comparisons – Upcoming ISES Dietary Symposium (Oct-2012) SHED-Dietary – Available through EPA/ORD website 23

24 Health Effects Division Office of Pesticide Programs Exposure Assessment Resources FCID Recipe Database http://fcid.foodrisk.org/ DEEM-WWEIA 2003-08 http://www.epa.gov/pesticides/science/deem/ SHEDS-Multimedia http://www.epa.gov/heasd/products/sheds_multimedia/sheds_mm.html 24

25 Health Effects Division Office of Pesticide Programs 25 Questions

26 Health Effects Division Office of Pesticide Programs Extra Slides 26

27 Health Effects Division Office of Pesticide Programs New Recipe Formation 27 Step 1 Identify food nutrients Step 1.A Conduct internet search to determine food description and ingredients (if necessary) Step 2 Search existing recipes for similar food Step 3 Use similar existing recipe as starting point for new recipe Step 4 Modify/add/delete recipe commodities to match new recipe nutrient information

28 Health Effects Division Office of Pesticide Programs Search Recipes by Food Name 28

29 Health Effects Division Office of Pesticide Programs Generate Recipe Report 29


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