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Drug hypersensitivity: Pharmacogenetics and clinical syndromes

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1 Drug hypersensitivity: Pharmacogenetics and clinical syndromes
Elizabeth J. Phillips, MD, Wen-Hung Chung, MD, PhD, Maja Mockenhaupt, MD, PhD, Jean-Claude Roujeau, MD, Simon A. Mallal, MBBS  Journal of Allergy and Clinical Immunology  Volume 127, Issue 3, Pages S60-S66 (March 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Translational roadmap from discovery of HLA-B∗5701 association with abacavir hypersensitivity to widespread clinical implementation. Journal of Allergy and Clinical Immunology  , S60-S66DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Number needed to test (NNT) to prevent 1 case of specific drug reaction. Numbers shown are for abacavir hypersensitivity, allopurinol-associated SJS/TEN/drug hypersensitivity, CBZ-associated SJS/TEN, and flucloxacillin-associated drug-induced liver disease. Adapted from Phillips and Mallal.24 Journal of Allergy and Clinical Immunology  , S60-S66DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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