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Immunologic defects in 22q11.2 deletion syndrome

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Presentation on theme: "Immunologic defects in 22q11.2 deletion syndrome"— Presentation transcript:

1 Immunologic defects in 22q11.2 deletion syndrome
Andrew McLean-Tooke, MRCP, Dawn Barge, PhD, Gavin P. Spickett, FRCP, Andrew R. Gennery, MD  Journal of Allergy and Clinical Immunology  Volume 122, Issue 2, Pages e4 (August 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Naive CD4+ T cells vs CD4+ RTE counts in patients and controls. The proportions in the CD4+ T-cell population (A) and absolute counts of naive (CD45RA+CD27+) vs RTE (CD45RA+CD31+; B) from controls (⋄) and patients (•) are shown. Correlation coefficients for patients: r = 0.929; controls: r = (A); patients: r = 0.979; controls: r = (B). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Absolute count and proportion of CD4+FoxP3+ nTreg cells with age in patients and controls. The proportion of nTreg cells in the CD4+ population (A) and absolute counts (cells/μL; B) of nTreg cells from controls (⋄) and patients (•) are displayed according to age in months. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Correlation between nTreg cells and RTEs in patients and controls. The absolute counts of nTreg cells and CD4+ RTEs (CD45RA+CD31+) from controls (⋄) and patients (•) are shown. Correlation coefficient for patients: r = 0.829; controls: r = Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Memory B cells in the B-cell population in patients and controls. Proportion of nonclass-switched memory B cells (CD27+IgM+IgD+; A) and class-switched “memory” B cells (CD27+IgM–IgD–; B) in the total B-cell population of controls (⋄) and patients (•) is displayed according to age group. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Phenotypic characterization of CD4+ RTEs,CD4+ naive T cells, and CD4+FoxP3+ regulatory T cells. A, The dot plot shows surface expression of CD31 and CD45RA RTEs. B, The dot plot shows surface expression of CD27 and CD45RA naive cells. C, The dot plot shows surface expression of CD4 and FoxP3 nTreg cells. The cells in A and B are gated on scatter and CD3+CD4+ T cells, and cells in C are gated on lymphocytes by scatter. FITC, Fluorescein isothiocyanate; PE, phycoerythrin; FL, fluorescent channel. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Absolute counts of peripheral blood lymphocyte populations in patients and controls. Data shown for 54 healthy controls (⋄) and 27 patients (•). Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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