1. The aging kidney Kidney International
Diego Rodrfguez-Puyol 
Kidney International 
Volume 54, Issue 6, Pages (January 1998)
DOI: /
Copyright © 1998 International Society of Nephrology Terms and Conditions

2. Fig. 1
Schematic representation of the aging process, considering the organism as the sum of Its different cells. Abbreviations are: ROl, reactive oxygen intermediates; AGE, advanced glycosylation end products; mediators, other possible mediators.
Kidney International  , DOI: ( / )
Copyright © 1998 International Society of Nephrology Terms and Conditions

3. Fig. 2
Morphologic changes in the renal cortex of 24-month-old Wistar rats. (1) Diffuse glomerular and tubular changes, with cystic appearance and atrophy of the glomerular tuft of some glomeruli, glomerulosclerosis, tubular dilation, and intratuhular casts (PAS X 100). (2) Tubular atrophy, reduplication of basal membranes, and interstitial expansion (PAS X 400). (3) Magnification of a sclerosed glomerulus. near another glomerulas with cystic appearance, in an area with interstitial expansion (PAS x 400). (4) Arteriolar hyalinosis (PAS x 600).
Kidney International  , DOI: ( / )
Copyright © 1998 International Society of Nephrology Terms and Conditions

4. Fig. 3
Expression of the collagen type-IV mRNA (α-i chain) in the renal cortex from 3-month-old (lanes 1 and 2) and 24-month-old (lanes 3 and 4) rats.
Kidney International  , DOI: ( / )
Copyright © 1998 International Society of Nephrology Terms and Conditions

5. Fig. 4
Expression of the TGF-β mRNA in the renal cortex from 3-month-old, 18-month-old, 24-month-old, and 30-month-old rats. Upper panel, the simultaneous amphtication of the TGF-pl and GAPDH (housekeeping gene) mRNAs by using RT-PCR, in samples from rats of different ages. Lower panel, the ratio between the two amplification products (TGFf 1/GAPDH) were calculated and the mean SCM of 6 different rats are given. *P < 0.05 versus 3-month-old rats. (Published with permission of JAm Soc Nephrol.)
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6. Fig. 5
Northern blot analysis of the expression of the preproendothelin-1 and GAPDH (housekeeping gene) mRNAs In 3.month-old and 24.month-old rats.
Kidney International  , DOI: ( / )
Copyright © 1998 International Society of Nephrology Terms and Conditions

7. Fig. 6
Northern blot analysis of the changes in the preproendothelin-I naRNA expression in cultured bovine aortic endothelial cells Incubated with hydrogen peroxide (100 μM) for different times (4 to 24 hours).
Kidney International  , DOI: ( / )
Copyright © 1998 International Society of Nephrology Terms and Conditions

8. Fig. 7
Northern blot analysis of the changes in the endothelial coasti. tutive nitric oxide synthase (NOS-3) mRNA expression (upper panel) and in the activity of this enzyme, measured as the conversion of arginiac to citrulline (lower panel), In cultured bovine aortic enclothelial cells incubated with xanthlne (X, 0.1 M) plus xanthlne oxidase (XO, 1 mU/mi) for different times (4 to 24 hours).
Kidney International  , DOI: ( / )
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9. Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994)
Copyright © 1998 International Society of Nephrology Terms and Conditions

10. Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994)
Copyright © 1998 International Society of Nephrology Terms and Conditions

11. Kidney International 1998 54, 2247-2265DOI: (10.1038/4499994)
Copyright © 1998 International Society of Nephrology Terms and Conditions