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Influenza A Virus Lures Autophagic Protein LC3 to Budding Sites

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Presentation on theme: "Influenza A Virus Lures Autophagic Protein LC3 to Budding Sites"— Presentation transcript:

1 Influenza A Virus Lures Autophagic Protein LC3 to Budding Sites
Christian Münz  Cell Host & Microbe  Volume 15, Issue 2, Pages (February 2014) DOI: /j.chom Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Influenza A Virus Redirects LC3B to the Cell Surface
Influenza A virus arrests autophagosome fusion with lysosomes via its matrix protein 2 (M2). This leads to perinuclear LC3B-coupled membrane accumulation. Via direct binding to LC3B M2 redirects LC3B and presumably the associated membranes to the cell surface for filamentous influenza A virus budding, which results in more stable viral particles. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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