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Alyssa Hasty, PhD Associate Professor Molecular Physiology and Biophysics.

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Presentation on theme: "Alyssa Hasty, PhD Associate Professor Molecular Physiology and Biophysics."— Presentation transcript:

1 Alyssa Hasty, PhD Associate Professor Molecular Physiology and Biophysics

2 Research, Scholarship or Creative Expression Teaching Service

3 Research, Scholarship or Creative Expression Teaching Service National Reputation

4 CV (formatted according to their guidelines) Documentation of Teaching Form Critical References (description of your 5 most important papers and why they impacted the field) Letters of Evaluation (minimum of 5) Letter from Chair/Chief of your department appointments-and-promotions#supportdocs


6 NameStatusDatesDid work result in publications? 1. Alli Nuotio-AntarPhD graduate student, Graduated April 2007 2004-20072 first author 1 co-author 2. Saraswathi ViswanathanPost-doctoral fellow2004-20074 first author 1 co-author 3. Kimberly R. CoenenPhD graduate student, Graduated March 2008 2004-20084 first author 3 co-author 4. Bonnie K. SurmiPhD graduate student, Expected graduation 2009 2006- present 2 first author 5. Michelle R. PlummerMasters degree student (MLI), Graduated January 2007 2005-20071 first author 4 co-author 6. Marnie L. GruenMasters degree student (MLI), Graduated January 2007 2005-20073 first author 5 co-author 7. Robin D. AtkinsonIMSD student2004-20061 first author 2 co-author 8. Michael J. PuglisiPost-doctoral fellow2008- present 1 co-author 9. Dario A. GutierrezPhD graduate student2008- present 1 first author 1 co-author 10. Nick KhooPost-doctoral fellow (visiting)2008Will result in at least 2 publications

7 The number differs by department


9 Please specify up to five references which represent the candidates most significant contributions. If the candidate if not first author, specify the role played by the candidate in the work described by these key publications. I have chosen the 5 most important and impactful papers out of 14 papers on which I am the senior corresponding author. These papers demonstrate the focus of my research program on mechanisms by which lipids induce macrophage inflammation. These inflammatory macrophages promote atherosclerotic lesion expansion when they are present in the arterial intima and insulin resistance when they are present in adipose tissue.

10 How did they change our scientific knowledge? Did they help you obtain grant funding? Did they help establish a collaboration? Did they bring you name recognition in some other way?

11 Literature Citation #1. Names of all authors as listed sequentially on the publication: Title: Role of Candidate: I am the senior, corresponding author on this manuscript. The experiments were performed by Saraswathi Viswanathan, a post-doctoral fellow in my laboratory at that time. I was responsible for interpretation of the data. The manuscript was drafted by Dr. Viswanathan, and finalized and submitted by myself.

12 This manuscript describes our observation that very low density lipoproteins (VLDL) induce inflammatory cytokine production in macrophages. In particular, we studied the time course and dose response expression of the chemokine, macrophage inflammatory protein-1α (MIP-1α). Furthermore, we showed that the increase in inflammatory gene expression coincided with the phosphorylation of the MAPK pathway members: ERK1/2, JNK, and p38 MAPK, and was ameliorated by U0126, an inhibitor of ERK1/2. Finally, inhibition of extracellular TG hydrolysis with Orlistat resulted in the absence of intracellular TG and FFA accumulation and was accompanied by the amelioration of ERK1/2 phosphorylation and MIP-1α gene expression. These results are important because hypertriglyceridemia is a hallmark characteristic of obesity-related dyslipidemia, and macrophages play a critical role in both atherosclerotic lesion formation and insulin resistance. Thus, we concluded that elevations in TG-rich VLDL may contribute to the pathogenesis of obesity by increasing inflammation in macrophages. These studies helped lay the foundation for both my American Diabetes Association grant to study MIP-1α in atherosclerosis and insulin resistance, as well as my NIH R01 to study the role of fatty acids in macrophage accumulation in adipose tissue.

13 These data have important implications to the pathogenesis of diet-induced obesity in humans, even when plasma lipid abnormalities are not present. This publication was also instrumental in helping me obtain my R01. In addition, they brought me recognition in the field of macrophage infiltration into AT, and I was subsequently asked to write two review articles on the topic.

14 Development of this mouse model has led to a collaborative effort between my laboratory and Drs. Judy Aschner, Jeff Reese, and BC Paria to study the impact of maternal obesity on the cardiovascular outcomes in the offspring. We have obtained P&F funding for this project and are currently obtaining preliminary data in order to submit a multi-PI NIH R01 application next year. In addition, Dr. Coenen and I will be writing a review article on mouse models of the metabolic syndrome to be submitted to the journal Disease Models and Mechanisms this Fall.

15 This publication has lead to the development of 4 new collaborations for my lab. (1) We are collaborating with Dr. Charles Wilkins at the University of Arkansas to assess phospholipid levels in tissues from these mice, and have a manuscript in submission. (2) We are collaborating with Dr. Alan Tall at Columbia University to determine the effect of fish oil on the phagocytic index of arterial macrophages. (3) We are collaborating with Dr. Edward Fisher at New York University to determine whether fish oil impacts apoB aggregation in liver. (4) We are collaborating with Dr. Naima Moustaid-Moussa at the University of Tennessee Knoxville to determine whether fish oil impacts adipose tissue expression of genes involved in the renin angiotensin system.


17 Nationally recognized leaders in relevant area of scholarship Colleagues but NOT collaborators Someone in the same research group as a collaborator Someone who has followed your career and has an interest in seeing you succeed Head of similar department as yours Could they say, this person would certainly be given T&P at my University – be aware of other University T&P policies. The most frequent reason for deferral of Committee action is the need to request additional information from additional correspondents.

18 Daniel Rader, MD University of Pennsylvania School of Medicine Theodore Mazzone, MD Professor of Medicine, University of Illinois at Chicago Chief, Section of Diabetes and Metabolism MC 797 Alan Daugherty, PhD, D.Sc. Professor of Medicine and Physiology Gill Foundation Chair in Preventive Cardiology Director, Cardiovascular Research Center Jay Heinecke, PhD Professor of Medicine Division of Metabolism, Endocrinology and Nutrition University of Washington School of Medicine Murray Huff, PhD Professor, Departments of Medicine and Biochemistry University of Western Ontario Ira Tabas, MD. PhD Professor of Medicine and Anatomy & Cell Biology, Department of Medicine Columbia University

19 gested-format-curriculum-vitae

20 Include all sections, even if N/A Follow SOM guidelines carefully Within these guideline, make as aesthetically pleasing as possible Dont assume the reviewers will know abbreviations that are common in your field There may be several months between when your department T&P committee meet to when your package is sent to the University T&P committee –submit your most current CV

21 Name Education Licensure and Certification Academic Appointments Hospital Appointments Employment Professional Organizations Professional Activities Teaching Activities Other Activities Research Program Publications and Presentations (separate by category) ls-appointments-and-promotions#guidelines


23 Research, Scholarship or Creative Expression (National Recognition)

24 Because a senior investigator at another institution cares about your career Trade invitations Invite yourself As part of collaboration Out of the blue

25 2002 – 1 2003 – 1 2006 – 3 2007 – 5 2008 – 5 2009 - 2 Only 4 of 17 were from people I did not know


27 Alan Daugherty Invitation to speak at UK Invitation to speak at ATVB Invitation to speak at Gordon Conference Invitation to be on ATVB planning committee


29 2003-2007American Heart Association Southeast/OhioValley Chapter Grant Committee (met Carole Stzalryd) We traded invitations 12/04/08 University of Maryland. Clinical Nutrition Research Unit Seminar.

30 2003-2007American Heart Association Southeast/OhioValley Chapter Grant Committee (met Suzanne Mohr) 12/10/07 Case Western Reserve University - Diabetes Research Seminar.


32 Met Pete Bodary at ATVB conference in 2006 We traded invitations 04/17/07 Wayne State University - Nutrition and Food Sciences Seminar Series.

33 Met Heddwen Brooks at a Womens Faculty Leadership conference We traded invitations 10/13/06 University of Arizona – Diabetes Seminar Series.


35 Met Alan Chait who spoke in DRTC seminar series I initiated a collaboration and invited myself to visit with him to discuss 11/15/07 University of Washington - Endocrinology Research Conference. Met Jay Heinecke at U Wash and again at a Gordon Conference

36 Met Martin Meyers who spoke in MPB seminar series 10/11/07 University of Michigan - Division of Metabolism, Endocrinology, and Diabetes Seminar Series. He won an award at the Obesity Conference last year and invited me to a party. I met Susan Fried there who is the current chair of the Obesity Society and asked me to speak at their next annual meeting.

37 Research, Scholarship or Creative Expression (National Recognition)

38 1.Articles in refereed journals: List chronologically 2.Books, book chapters, invited review articles 3.Letters to editor, book reviews, editorials (optional) 4.Abstracts (optional) 5.Presentations at Scientific Meetings

39 Separate by category Doesnt say you cant include In Submission or In Revision I would not include In Preparation

40 Total 56 original 2 reviews 1 book chapter 23 were first author or from my lab From 2003 27 original 2 reviews 1 book chapter 17 were from my lab

41 Research, Scholarship or Creative Expression (National Recognition)

42 Previous P&Fs and Junior Faculty Grants ADA Career Development Award R01 Choice of Study Section and NIH Institute is VERY important

43 Found an exceptional lab manager who has been with me since day 1 Spent my development funds to hire people so that I published fairly early Wrote for and obtained junior faculty grants early My development funds lasted longer Showed evidence of obtaining funding Department paid to have my R01 read by outside person Used my mentoring committee for advice

44 The wrong person is not better than no person. Even while working on projects you have funded, look toward the future of where your field will be going next. If you are moving away from a certain direction, finish and publish those studies as quickly as possible. Do NOT avoid conflict – especially if it is with someone in your lab group.

45 Find out who is on the T&P committee and talk to them about your CV Set up a meeting with Dr. Penn or Dr. Raiford to talk about your CV You NEED someone on your side in your department for when you are discussed! Reserve time on your calendar to read/write Pay it forward.

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