1. Induction of Sox9 in response to renal injury and during repair (Kumar et al.63).
Induction of Sox9 in response to renal injury and during repair (Kumar et al.63). (A) Before injury, no evidence of expression of Sox9 or KIM1 is seen in the tubular epithelium. (B) Upon injury (unilateral ureteric obstruction or IRI), there is rapid upregulation of Sox9 (yellow nuclei) which preceded expression of Kim1 (black cell border). Cells induced to express Sox9 represented a subset of the injured epithelium as evidenced by cells inducing Kim1 without evidence of Sox9. (C) Sox9 expression levels peaked at 24–48 hours, as did serum creatinine levels and apoptosis. Approximately 40% of Sox9 cells showed evidence of proliferation (dark blue). (D) Elevation in expression of Sox9 persisted for 28 days despite a return to normal of renal functional readouts. At 28 days post injury, those tubules showing a failure to return to maximal labeling lotus tetragonolobus lectin and contained cells that were Sox9+KIM1+. Adapted with permission from Macmillan Publishers Ltd: Nature Reviews Nephrology, Ref. 122, copyright 2013.
Melissa Helen Little, and Pamela Kairath JASN 2017;28:34-46
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