1. Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running 
T.J. Mosher, Y. Liu, C.M. Torok 
Osteoarthritis and Cartilage 
Volume 18, Issue 3, Pages (March 2010)
DOI: /j.joca
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
Anatomic landmarks are indicated on a representative sagittal 3.0T source image (TR/TE: 1500ms/36ms) obtained from the lateral femoral/tibial compartment. The anterior and posterior margin of the meniscus (dashed lines) define the boundaries for the cartilage analysis. For subregional analysis presented in Fig. 6, the free edge of the anterior and posterior horn defined the limits of the central regions (cLF, cLT). Cartilage adjacent to the posterior horn defined the posterior regions (pLF, pLT).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Graphs of mean thickness (±standard error of the mean) for (a) femoral and (b) tibial cartilage before (grey bar) and after (black bar) 30min of running exercise for the 4 groups: YC – young control group, YM – young marathoner group, OC – old control group, OM – old marathoner group. P values refer to paired two-tailed t-test comparing before and after exercise cartilage thickness measurements. All groups demonstrate a decrease in cartilage thickness after running, which was statistically significant in the young cohorts. Less cartilage deformation was observed in older groups compared to young groups independent of level of physical activity.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Representative quantitative sagittal cartilage T2 maps from two runners (A) 25-year-old female runner with 10 years of running experience, averaging 12 miles per week. (B) 47-year-old male runner with 15 years of experience, averaging 20 miles per week. Both subjects demonstrate similar spatial variation in cartilage T2 with increased values (red) observed near the articular surface. After running there is loss of red voxels in the central and posterior femoral cartilage indicative of a decrease in cartilage T2.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

5. Fig. 4
Baseline cartilage T2 values as a function of depth from the articular surface for (A) central femur and (B) tibia cartilage. There was no statistically significant difference in baseline cartilage T2 values as a function of age or level of physical activity.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

6. Fig. 5
Change in cartilage T2 values after 30min of running for (A) central femur and (B) tibia cartilage. (*) indicates the changes in cartilage T2 was statistically significant (P<0.05). For all groups there was a statistically significant decrease in superficial femoral cartilage, and in superficial tibial cartilage for all but the YC group. No statistically significant change in T2 was observed in the deep layer of cartilage. There was no significant difference in change in cartilage T2 after running based on age or level of physical activity.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

7. Fig. 6
Change in superficial cartilage T2 based on location in the femoral/tibial joint (pooled values for all subjects). cMF, cLF, pMF, pLF, cMT, cLT, pMT, pLT. All locations with the exception of the pMT region demonstrated a statistically significant decrease in cartilage T2, with no statistically significant difference based on location.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions