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An Activation Marker Finds a Function

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1 An Activation Marker Finds a Function
Diana M. Mitchell, Matthew A. Williams  Immunity  Volume 32, Issue 1, Pages 9-11 (January 2010) DOI: /j.immuni Copyright © 2010 Elsevier Inc. Terms and Conditions

2 Figure 1 CD44 Prevents Fas-Mediated Apoptosis during Th1 Cell Clonal Expansion After activation in response to influenza infection, Th1 cells upregulate CD44, overcome Fas-induced death signals, undergo clonal expansion, and populate the memory pool after pathogen clearance. In the absence of CD44 signals, clonally expanding T cells undergo Fas-mediated apoptosis and fail to progress to the memory cell pool. Immunity  , 9-11DOI: ( /j.immuni ) Copyright © 2010 Elsevier Inc. Terms and Conditions


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