Presentation on theme: "Cure or Catastrophe: Newcastle Disease Virus Cancer Research and Mass Media Coverage Ryan Smith Professional Practices EGR 108.007 Mercer University School."— Presentation transcript:
Cure or Catastrophe: Newcastle Disease Virus Cancer Research and Mass Media Coverage Ryan Smith Professional Practices EGR 108.007 Mercer University School Of Engineering
Objectives 1.A brief History of Newcastle Disease Virus (NDV) 2.Current clinical studies and research on NDV and cancer 3.The effect of mass media reporting on public perception
Viruss 1.What is a virus: A micro organism smaller than a bacteria that can reproduce apart from a living cell 1.Can be made of either DNA (deoxyribonucleic acid) or RNA ( ribonucleic acid) For a better visual, click herehere
Newcastle Disease Virus NDV is a type of avian (bird) retrovirus that causes illness in a wide variety of birds, but most notably in chickens. The symptoms (in birds) includes swelling in the respiratory tract (lungs), brain, and/or gastrointestinal tract (intestines). Retrovirus
NDV can infect people, but it is not very virulent (toxic): -mild flu-like symptoms -conjunctivitis (red, runny eyes) -laryngitis (hard to talk) NDV in Humans
NDV is a retrovirus Retrovirus means that it uses RNA RNA is a short genetic sequence that cells use to reproduce DNA (which is our genetic material) RNA viruss tend to be more deadly Use a RNA encoding to quickly turn cells into factories Mercer university School of Engineering EGR 108.007 By: Ryan Smith This box was placed here to prove that This document is the property of Mercer University and Ryan Smith
NDV facts and review NDV is an avian flu that can infect people, of which when infecting humans it usually results in flu-like symptoms NDV replicates better in Human Tumor Cells than in normal cells NDV has both lytic and non-lytic strains Lytic and non-lytic are two different methods of virus reproduction, differences being that the lytic cycle destroys the cell and releases the virus and the non-lytic simply remains in the DNA of the infected cell and uses the cell to make more infected cells NDV reproduces 10,000 times faster inhuman cancer cells which has attracted scientists to investigate its potential in cancer research
Lytic cycle and Non-lytic/Lysogenic cycle Lysogenic Cycle
Current Research 3 different approaches to cancer treatment are being looked at: –Lytic strain of NDV- the infection of cancer patients with a strain of NDV –Oncolysate vaccine- using fragments of the virus as an anticancer vaccine –Whole cell vaccine- use of intact cancer cells with a non-lytic strain of NDV as a Whole cell vaccine
The anticancer potential of NDV has been investigated in clinical studies in the US, Germany, and Hungary It was reported that they have seen some improvement in: -Improved disease free survival -Complete/partial tumor response -NDV has in isolated studies shown the potential to cure: Melanoma, Renal, Breast, Ovarian, and many other types of cancer. Current Research with NDV
Research Results NDV-based anticancer therapy has been reported to be of benefit in more than a dozen clinical trials, but according to the Physician Data Query Cancer Clinical Complementary and the Alternative Medicine Editorial Board, the results of these studies should be considered inconclusive because the study designs were weak and the study reports were incomplete.
Effect of mass media (television) Most people today get their information from television. However, the information on television tends too be inaccurate, based more on professional opinion and exaggerated hopes. In an article by Fowler and Goldstein, they concluded that a lot of airtime is spent on Health stories and those stories are seen by about 165 million Americans. However, few of these stories focused on Newcastle and some even had incorrect and potentially harmful information.
Canadian Medical Association Journal (CMAJ) An article published in CMAJ stated The public gets most of its information about genetics research from the media. Results found only 11% of the newspaper articles were categorized as having moderately to highly exaggerated claims and that 97% of the newspaper articles and 98% of the scientific journal articles discussed the likelihood of benefits of the research.
CMAJ Conclusion The majority of newspaper articles accurately conveyed the results of and reflect the claims made in scientific journal articles.
Medical News for the Public To Use? Whats on Local TV News by Pribble, Goldstein, Fowler, Greenberg, Noel and Howler According to this article local television is the major source of information for most Americans and media reporting has increased significantly during the past 10 years. Regularly reaches 165 million people 2795 Broadcasts, 1799 health stories aired were reviewed in this article They concluded that local TV devotes a lot of airtime to health stories yet few focus newscasts on useful information and some stories with factually incorrect information and potentially dangerous advice were aired.
Do the print media hype genetic research? A comparison of newspaper stories and peer- reviewed research papers by Bubela and Caulfield According to this article the public gets most of its information about genetics research from the media. They looked at whether or not the media representations may involve exaggerations called Geno-hype. They found that the majority of articles accurately conveyed the results of and reflect the claims made in the articles reviewed.
Mass Media and Medicine: Challenges and Opportunities Journal of American Medical Association According to this article while misrepresentations of medical information by mass media can have negative consequences, the use of mass media to educate the public about medicine has an enormous potential to do good.
Conclusion NDV is an exciting area of research with great potential to impact cancer research, treatment and recovery. Many studies although weak and not well controlled show some potential to be of benefit. Mass media that includes magazines, television, radio stations and newspapers can have an enormous impact-both positive and negative on an individuals health and life. It is crucial that the reporting of health news be factual and that reporting errors be eliminated.
Works cited 1. National Cancer Institute (2008). Newcastle Disease Virus (PDQ®). March 18, 2008 from http://www.cancer.gov/cancertopics/pdq/cam/NDV/patient http://www.cancer.gov/cancertopics/pdq/cam/NDV/patient Information was gathered here so that a cancer patient could get the pros and cons about Newcastle treatment 2. National Cancer Institute (2008). Newcastle Disease Virus (PDQ®). March 18, 2008 http://www.cancer.gov/cancertopics/pdq/cam/NDV/HealthProfessional http://www.cancer.gov/cancertopics/pdq/cam/NDV/HealthProfessional The information here is for doctors too read and get a more indepth understanding about what the Newcastle treatment really is 3. Csatary, L. K., & Eckhardt, S., & Bukosza, I., & Czegledi, F., & Fenyvesi, C., & Gergely, P., & Bodey, B., & Csatary, C. M. (1993). Attenuated veterinary virus vaccine for the treatment of cancer. 17(6), 619-27. http://www.ncbi.nlm.nih.gov/pubmed/8275514?ordinalpos=5&itool=EntrezSystem2.PEntr ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum This study was conducted during the beginnings of the Newcastle study. It is informative only if you wanted too see how far they have come
Works cited 4. Nakaya, T., & Cros, J., & Park, M., & Nakaya, Y., & Zheng, H., & Sagrera, A., & Villar, E., & García-Sastre, A., & Palese, P. (2001). Recombinant Newcastle Disease Virus as a Vaccine Vector. Journal of Virology. 75(23), 11868– 11873. This article is a study on the effects of NDV 5. Park, A. (2006, January 1). How to make a better vaccine. Time, Error, can not find correct information from cite This article is how the opinion of the media can be taken into account 6. Janke, M., & Peeters, B., & de Leeuw, O., & Moorman, R., & Arnold, A., & Fournier, P., & Schirrmacher, V. (2007). Recombinant Newcastle disease virus (NDV) with inserted gene coding for GM-CSF as a new vector for cancer immunogene therapy. Nature, 14, 1639–1649 Another study of NDV
Works Cites (continued) 7. Young, J. S., (2002, February 13) Mass Media and Medicine: Challenges and Opportunities. JAMA. 287 (6), 772. This article is about how the media tends to overexagerate medical findings and how medical commercials can be misleading 8. Wilson, K., & Code, K., & Dornan, C., & Ahmad, N., & Hébert, A., & Graham, I. (2004, January 5). The reporting of the theoretical health risks by the media: Canadian newspaper reporting of potential blood transmission of Creutzfeldt-Jakob disease. BMC Public Health. 4 (1), 1471-2458. This article was about how the media tries to convey information to the public and also what they include. Also it gives suggestions on how to improve the accuracy of the information 9. Vastag, B. (2003, February 12) Openness in Biomedical Research Collides With Heightened Security Concerns. JAMA. 289 (6), 686-690 The security risks of presenting all medical findings to the media. 10. Pribble, J. M., &Doldstein, K. M., & Fowler, E. F., & Greenberg, M. J., & Noel, S. K., & Howell, J. D. (2006, March) Medical News for the Public to Use? Whats on Local TV News. Trends from the field. (12) 170-176 It evaluates health topics and reports charectoristics of health stories in local television news across the US