Presentation is loading. Please wait.

Presentation is loading. Please wait.

Nat. Rev. Rheumatol. doi: /nrrheum

Published byHerman Teves Chagas Modified over 6 years ago

Similar presentations

Presentation on theme: "Nat. Rev. Rheumatol. doi: /nrrheum"— Presentation transcript:

1 Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.134
Figure 2 Pathological effects of anti-GPCRs autoantibodies interfering with neuronal transmission Figure 2 | Pathological effects of anti-GPCRs autoantibodies interfering with neuronal transmission. Autoantibodies against the muscarinic acetylcholine receptor 3 (M3) block the secretion of saliva and tears in exocrine glands (upper left panel), as well as the neural transmission required for gastrointestinal motility50,51 (upper right panel). Antagonistic autoantibodies targeting β2-adrenergic receptor (β2AR) impair vasodilatation and bronchodilatation, which are controlled by β2AR in intrapulmonary airways29 (lower left panel). Anti-β1 adrenergic receptor (β1AR)-specific autoantibodies can increase the beating rate of cardiomyocytes and hence are potentially involved in the pathogenesis of cardiomyopathies37,38,39 (lower right panel). GPCRs, G protein-coupled receptors. Cabral-Marques, O. & Riemekasten, G. (2017) Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases Nat. Rev. Rheumatol. doi: /nrrheum

Download ppt "Nat. Rev. Rheumatol. doi: /nrrheum"

Similar presentations

Why Study the Autonomic Nervous System?

Why Study the Autonomic Nervous System?
Dr. Zahoor 1. Q.1 What is Autonomic Nervous System (ANS)? Q2. What are the divisions of ANS? Q3. Give the origin of Sympathetic ANS and Parasympathetic.

Dr. Zahoor 1. Q.1 What is Autonomic Nervous System (ANS)? Q2. What are the divisions of ANS? Q3. Give the origin of Sympathetic ANS and Parasympathetic.
Figure 3 The induction of anti-DNA antibodies by bacterial DNA

Figure 3 The induction of anti-DNA antibodies by bacterial DNA
Figure 1 Role of innate lymphoid cells (ILCs) in steady state,

Figure 1 Role of innate lymphoid cells (ILCs) in steady state,
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 3 Example of how a noncoding regulatory rheumatoid

Figure 3 Example of how a noncoding regulatory rheumatoid
Figure 2 A timeline summarizing the development of diagnostic tools in rheumatology Figure 2 | A timeline summarizing the development of diagnostic tools.

Figure 2 A timeline summarizing the development of diagnostic tools in rheumatology Figure 2 | A timeline summarizing the development of diagnostic tools.
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Factors underlying metabolic alterations in osteoarthritis

Figure 1 Factors underlying metabolic alterations in osteoarthritis
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Figure 1 Structure of TNF antagonists

Figure 1 Structure of TNF antagonists
Figure 1 Induction of immune tolerance

Figure 1 Induction of immune tolerance
Figure 1 The role of GPCRs in the regulation of human physiology

Figure 1 The role of GPCRs in the regulation of human physiology
Figure 2 Heat map of targeted therapies in autoimmune diseases

Figure 2 Heat map of targeted therapies in autoimmune diseases
Figure 2 Main functions of IL-1

Figure 2 Main functions of IL-1
Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum
Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio
Figure 4 Involvement of SEMA4D in the pathogenesis

Figure 4 Involvement of SEMA4D in the pathogenesis
Figure 2 Targeted versus untargeted metabolomics approaches

Figure 2 Targeted versus untargeted metabolomics approaches

Similar presentations

Ads by Google