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Choice of Better Laboratory Technique for the Preparation of Microspheres Applying Analytical Hierarchy Process: A Case Study P.Venkatesan Lecturer, Annamalai.

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Presentation on theme: "Choice of Better Laboratory Technique for the Preparation of Microspheres Applying Analytical Hierarchy Process: A Case Study P.Venkatesan Lecturer, Annamalai."— Presentation transcript:

1 Choice of Better Laboratory Technique for the Preparation of Microspheres Applying Analytical Hierarchy Process: A Case Study P.Venkatesan Lecturer, Annamalai university Annamalainagar 608002 Tamilnadu, India OTECH - 8

2 Choice of Better Laboratory Technique for the Preparation of Microspheres Applying Analytical Hierarchy Process: A Case Study P.Venkatesan 1 *, C.Muralitharan 2, R.Manavalan 1 and K.Valliappan 1 Annamalai university, Annamalainagar, Tamilnadu, India.

3 OBJECTIVE The objective of the case study is to select an appropriate technique that would deliver the quality product with reproducibility of release profile and consistency with good entrapment efficiency by applying Analytical Hierarchy Process (AHP) technique.

4 INTRODUCTION Microencapsulation Microencapsulation is a process by which relatively thin coatings are applied to small particles of solids or droplets of liquids and dispersions. They usually have particle size ranging from several tenths of a micron to 5000 micron

5 APPLICATIONS This technology has been used widely in the design of controlled release and sustained release dosage forms. To mask the bitter taste of drugs like Paracetamol, Nitrofurantoin etc. To reduce gastric and other G.I. tract irritations. A liquid can be converted to a pseudo-solid for easy handling and storage. eg.Eprazinone. To provide protection to the core materials against atmospheric effects, e.g. Vit.A.Palmitate.

6 METHODS OF MICROENCAPSULATION Air Suspension Coating Thermal Change Incompatible Polymer Addition Non-Solvent Addition Salt Addition Polymer-Polymer Interaction Multi orifice - Centrifugal Process Solvent Evaporation Spray Drying and Spray Congealing Pan Coatings Coacervation Phase Separation.

7 ANALYTIC HIERARCHY PROCESS (AHP) Analytical Hierarchy Process developed by Thomas L.Saaty is one of the very effective Multi criteria decision making (MCDM) Model. This has been employed very successfully in many situations where a decision situation is characterized by a multitude of complementary and conflicting factors.

8 Saatys nine-point comparison scale Intensity of importance Definition Explanation 1Equal importanceTwo activities constitute equally to the objective 3.Moderate importanceExperience and judgment of one over another slightly favour one activity over another 5.Essential or strong importanceExperience and judgment strongly favour one over another 7.Very strongly demonstrated importance An activity is favoured very strongly over another; its dominance demonstrated in practice 9.Absolute importanceThe evidence favouring one activity over another is of highest possible order of affirmation 2,4,6,8Intermediate values between adjacent scale values When compromise is needed Reciprocals of above non zero If activity i has one of the above non zero numbers assigned to it when compared with activity j, then j has the reciprocal value when compared with i

9 METHODOLOGY AND EXPERIMENTAL WORK The case study was conducted with an objective to choose the better technique between four alternatives, namely Solvent Evaporation (SET), Coacervation Phase Separation (CAP) Pan Coatings (PAN) Spray Drying and Spray Congealing (SPR) for carrying out microencapsulation.

10 Overall objective Identify relevant criteria Identify alternatives to be rated Develop matrix of pair wise comparison of Calculate normalized weights of criteria Calculate consistency ratio (CR) of pairwise comparison matrix IS CR 0.10 yesNO

11 Develop matrix of pairwise alternatives with respect to each Calculate normalised weights of alternatives Have alternatives been compared Calculate the overall weight of each alternative IS CR 0.10 yes NO consistency ratio of pair wise comparison of alternatives Choose the best alternative Choose a the next yes NO yes

12 1. Process Information [PI] Production scale[PS]Lab scale, Pilot scale, Industrial scale Process condition[PC]Temperature, Stirring speed, Ph 2. Operation Skill [OS] Technique[MET] Microencapsulation is a process where by small discrete solid particles or liquid droplets are surrounded and enclosed by an intact shall Knowledge[KN]Refers to Microencapsulation theoretical background Training[TR]Hands on training on instrument 3. Supplier [SUP] Availability[AV]How easily the machine can be procured. Experience[EX]Reputation of the Supplier Service[SE]Serving and maintenance facilities Spares[SP]Availability of spare parts Monopoly[MO]Vendor status single/Multi Vendor

13 4. Technical information [TEI] Literature[LT]Scientific Journal, News, magazines updating current trends Manual[MA]Operational and service manual. 5. Technical Status [TES] Establish Technique[ET] Standing of the technique in the global level research Growth[GH] Growth in the field of encapsulation technique 6. Machine [MAC] Versatility[VE] Operational Flexibility, RPM, Encapsulation Complexity[CO] Complexity of the machine how easily one can handle the instrument

14 Using the AHP model the priority weights, [PR_WT], to the attributes and sub-attributes are calculated by pair wise comparison matrix Evaluation criteria C1C2C3...Cm C11 Reciprocal of entries below the diagonal C2 Degree of preferences of C2 versus C1 1 C3C3 versus C1C3 versus C21 CmC3 versus C1Cm versus C2Cm versus C3...1


16 RESULTS AND DISCUSSION In the case study, AHP technique was applied to make choice amongst alternative microencapsulation techniques (SET/CAP/PAN/SPR) and thereby opt the best technique. The composite score is used for the final ranking of the alternatives. The solution of the problem involves finding the composite score that reflects the relative priorities of all the alternatives at the lowest level of the hierarchy.

17 AttributesNotationPR_WT Sub- attributes PR_WT SETCAPPANSPR Process Information PI0.421 PS0.250.5910.2470.049PS PC0.750.5590.3230.058PC Operation skill OS0.261 MET0.4550.5580.2630.056MET KN0.4550.5580.2630.056KN TR0.0900.469 0.063TR SupplierSUP0.153 AV0.3340.5300.3110.096AV EX0.3330.450 0.049EX SE0.1110.450 0.049SE SP0.1110.450 0.049SP MO0.1110.438 0.081MO

18 AttributesNotationPR_WT Sub- attributes PR_WT SETCAPPANSPR Technical information TEI0.094 LT0.2500.5200.2970.124LT MA0.7500.5200.2970.124MA Technical status TES0.046 ET0.8330.6380.2300.0550.073 GR0.1670.6380.2300.0550.073 MachineMAC0.025 VE0.7500.5350.3270.0910.044 CO0.2500.5350.3270.0910.044 Composite score 0.5210.3050.0640.076

19 It is seen here that, PI is most important (priority = 0.421) followed by OS (priority = 0.261) and so on. In the next level of comparison, sub-attributes are compared with each other with respect to an attribute at a higher level. For instance, within PI the sub-attributes PS, PC are compared. Similarly in all the other sub-attributes are compared. The composite score favored the selection of SET (score=0.5216) over CAP (score=0.3059), PAN (score=0.0645), SPR (score=0.0769) for microencapsulation technique

20 CONCLUSION In today competitive scenario, an effective framework for selecting a technique for the preparation of microspheres using AHP as MCDM tool is presented in this case study here. This approach is a systematic one and it includes both quantitative and qualitative factors. Software for computing priority weights can be easily developed else commercial software (expert choice) is available.

21 The factors considered here are illustrative only and these may vary from case to case. The proposed approach can be extended to other situations like selection of alternatives such as tablets formulation machines, characterization technique like pharmacokinetic studies, release behavior, drug content, etc.

22 References Mine Qrlu, Erdal Cevher, Ahmet Araman(2006). Design and evaluation of colon specific drug delivery system containing flurbiprofen microspheres. International Journal of pharmaceutics. Doi:10.1016/J.ijpharm. 2006.03.025. Frederic Lagarce a,b et al(2004).Baclofen loded microspheres:Preparation and efficacy testing in a rabbit model. European journal of pharmaceutics and Biopharmaceutics 59:449-459.

23 microspheres containing Zedoary turmeric oil by the emulsion– solvent-diffusion method and evaluation of the self-emulsification and bioavailability of the oil.colloides and surfaces B:Biointerfaces 48:35-41. Khawla Abu-Izza et al (1996).Preparation and evaluation of Zidovudine- Loded sustained release microspheres: Optimization of multiple response Variables. Journal of Pharmaceutical sciences85:572-575. Yan Gao. of roxithromycin- polymeric microspheres by the emulsion solvent diffusion method for the taste journal of pharmaceutics. Doi:10.1016/j.ijpharm.2006.03.018.


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