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Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors  Neal I. Lindeman, Philip T. Cagle, Mary.

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Presentation on theme: "Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors  Neal I. Lindeman, Philip T. Cagle, Mary."— Presentation transcript:

1 Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors  Neal I. Lindeman, Philip T. Cagle, Mary Beth Beasley, Dhananjay Arun Chitale, Sanja Dacic, Giuseppe Giaccone, Robert Brian Jenkins, David J. Kwiatkowski, Juan-Sebastian Saldivar, Jeremy Squire, Erik Thunnissen, Marc Ladanyi  The Journal of Molecular Diagnostics  Volume 15, Issue 4, Pages (July 2013) DOI: /j.jmoldx Copyright © 2013 College of American Pathologists, American Society for Investigative Pathology, Association for Molecular Pathology, and the International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Negative for ALK rearrangement (original magnification × 1000). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2013 College of American Pathologists, American Society for Investigative Pathology, Association for Molecular Pathology, and the International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Positive for ALK rearrangement (split 3′ ALK-5′ ALK) (original magnification ×1000). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2013 College of American Pathologists, American Society for Investigative Pathology, Association for Molecular Pathology, and the International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Positive for ALK rearrangement (single 3′ ALK) (original magnification ×1000). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2013 College of American Pathologists, American Society for Investigative Pathology, Association for Molecular Pathology, and the International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Negative for ALK rearrangement with ALK high copy number (original magnification ×1000). The Journal of Molecular Diagnostics  , DOI: ( /j.jmoldx ) Copyright © 2013 College of American Pathologists, American Society for Investigative Pathology, Association for Molecular Pathology, and the International Association for the Study of Lung Cancer Terms and Conditions

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