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Outcomes of Sublobar Resection Versus Lobectomy for Stage I Non–Small Cell Lung Cancer: A 13-Year Analysis  Amgad El-Sherif, MD, William E. Gooding, MS,

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Presentation on theme: "Outcomes of Sublobar Resection Versus Lobectomy for Stage I Non–Small Cell Lung Cancer: A 13-Year Analysis  Amgad El-Sherif, MD, William E. Gooding, MS,"— Presentation transcript:

1 Outcomes of Sublobar Resection Versus Lobectomy for Stage I Non–Small Cell Lung Cancer: A 13-Year Analysis  Amgad El-Sherif, MD, William E. Gooding, MS, Ricardo Santos, MD, Brian Pettiford, MD, Peter F. Ferson, MD, Hiran C. Fernando, MD, Susan J. Urda, BS, James D. Luketich, MD, Rodney J. Landreneau, MD  The Annals of Thoracic Surgery  Volume 82, Issue 2, Pages (August 2006) DOI: /j.athoracsur Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Small peripheral lesion where substantial surgical margin can be obtained with sublobar resection. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Larger, more central lesion where compromised margin may occur with sublobar resection. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Distribution of tumor histologic diagnosis.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Disease-free survival by stage with 95% confidence intervals at 2-year intervals. Patients with sublobar resection (dashed lines) had similar disease-free survival compared with patients receiving lobectomy (solid lines) if they were stage IA (A; log-rank test, p = 0.308), but worse disease-free survival if they were stage IB (B; log-rank test, p = ). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Marginal and conditional estimates of overall survival by type of resection with 95% confidence intervals at 2-year intervals. When considered alone, sublobar resection conveys a worse prognosis for overall survival (A). The marginal effect of sublobar resection lowers 5-year survival from 54% in the lobectomy group to 40% in the sublobar group (log-rank test, p = ). However, when adjusted for other significant predictors, sublobar resection has no effect on overall survival. This is equally true for patients with limited (B) or extensive (C) node sampling. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2006 The Society of Thoracic Surgeons Terms and Conditions

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