1. Strategies for Assessing and Preserving Function in ALS

3. This program will include a discussion of investigational entities not approved by the FDA for use in the United States.

4. An Introduction to ALS

5. Respiratory Function in ALS

6. Case 1: History

7. Case 1: Examination and Testing

8. Case 1: Interventions

9. Case 2: History

10. Case 2: Examination and Testing

11. Case 2: Interventions

12. Bulbar vs Limb-Onset ALS

13. Improving NIV Tolerance in ALS

14. PFTs in ALS

15. Early NIV

16. Standard Indications for NIV

17. Case 3:

18. Case 3:

19. Case 3:

20. Case 3:

21. Long-Term Mechanical Ventilation

22. Diaphragm Pacing

23. Respiratory Outcome Measures in Clinical Trials for ALS

24. Conclusions

25. Abbreviations

26. Abbreviations