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Nonmalignant late effects after allogeneic stem cell transplantation

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Presentation on theme: "Nonmalignant late effects after allogeneic stem cell transplantation"— Presentation transcript:

1 Nonmalignant late effects after allogeneic stem cell transplantation
by Gérard Socié, Nina Salooja, Amnon Cohen, Attilio Rovelli, Enric Carreras, Anna Locasciulli, Elisabeth Korthof, Joachim Weis, Vincent Levy, and André Tichelli Blood Volume 101(9): May 1, 2003 ©2003 by American Society of Hematology

2 Interrelationship between total body irradiation, chronic graft-versus-host disease in the genesis of late complications after allogeneic stem-cell transplantation. Interrelationship between total body irradiation, chronic graft-versus-host disease in the genesis of late complications after allogeneic stem-cell transplantation. Gérard Socié et al. Blood 2003;101: ©2003 by American Society of Hematology

3 Factors contributing to late immune deficiency and late infection following allogeneic stem cell transplantation. Factors contributing to late immune deficiency and late infection following allogeneic stem cell transplantation. Gérard Socié et al. Blood 2003;101: ©2003 by American Society of Hematology

4 Cataract formation after TBI
Cataract formation after TBI.(A) Cataract formation occurs earlier after single dose than after fractionated dose total body irradiation (reprinted from Tichelli et al27 with permission). Cataract formation after TBI.(A) Cataract formation occurs earlier after single dose than after fractionated dose total body irradiation (reprinted from Tichelli et al27 with permission). (B) Fractionated TBI is associated with a significant, dose-dependent risk of cataract formation (reprinted from Benyunes et al28 with permission, nonexclusive world English rights only). Gérard Socié et al. Blood 2003;101: ©2003 by American Society of Hematology

5 Avascular necrosis of the hip
Avascular necrosis of the hip.Standard radiography versus MRI as a tool for the diagnosis of avascular necrosis. Avascular necrosis of the hip.Standard radiography versus MRI as a tool for the diagnosis of avascular necrosis. These panels illustrate that standard radiography could be strictly normal at the first clinical sign while MRI is already highly abnormal. The top panel shows the normal appearance of the hip using standard radiography. The middle and bottom panels show 2 different MRI sequences showing that, although the femoral head is still spherical, the adjacent bone is already affected with necrosis, with even cartilage modification. Gérard Socié et al. Blood 2003;101: ©2003 by American Society of Hematology


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