1. Acute kidney injury following proton pump inhibitor therapy
U.C. Brewster, M.A. Perazella 
Kidney International 
Volume 71, Issue 6, Pages (March 2007)
DOI: /sj.ki
Copyright © 2007 International Society of Nephrology Terms and Conditions

2. Figure 1
Light microscopy reveals normal appearing glomerulus (arrow) with diffuse cellular infiltrate in the interstitium (arrowhead) (hematoxylin and eosin stain).
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

3. Figure 2
Light microscopy demonstrates diffuse cellular infiltrate within the interstitium. The infiltrate consists of eosinophils (arrowhead) and lymphocytes. Tubulitis is also present (arrow) (hematoxylin and eosin stain).
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

4. Figure 3
Bar graphs demonstrating the clinical features of methicillin-induced AIN (longitudinal bars), non-methicillin drug-induced AIN (excluding non-steroidal anti-inflammatory drugs) (horizontal bars), and PPI-induced AIN (Geevasinga data, square pattern bars; other PPI cases combined, solid bars). Abbreviations: AIN, acute interstitial nephritis; NSAIDs, non-steroidal anti-inflammatory drugs; PPI, proton pump inhibitor, Hem, hematuria; Pro, proteinuria; RF, renal failure; Pyu, pyuria; Eos, eosinophilia.
(Adapted in part from;16 with permission).
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions

5. Figure 4
Calculated creatinine clearance of 18 patients with PPI-induced AIN at various time points before, during and after exposure to PPIs. Abbreviations: PPI, proton pump inhibitor.
(Adapted from;15 with permission).
Kidney International  , DOI: ( /sj.ki )
Copyright © 2007 International Society of Nephrology Terms and Conditions