1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2015.225
Figure 1 Timeline of discoveries and advances in the tau research field
Figure 1 | Timeline of discoveries and advances in the tau research field. Pivotal discoveries are shaded blue, and other major advances are shaded grey. These findings substantially enhanced our understanding of the aetiopathogenesis of neurofibrillary degeneration in Alzheimer disease (AD) and other tauopathies, and aided the identification of biomarkers and therapeutic targets. Additional major findings are summarized in Supplementary information S1 (box). CSF, cerebrospinal fluid; FTDP-17, frontotemporal dementia with parkinsonism linked to chromosome 17; I2PP2A, PP2A inhibitor 2; NFT, neurofibrillary tangle; PHF, paired helical filament; PP2A, protein phosphatase 2A; P-tau, hyperphosphorylated tau.
Iqbal, K. et al. (2015) Tau and neurodegenerative disease: the story so far
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