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Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction Figure 1 | The epigenetic landscape mediates the interplay.

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Presentation on theme: "Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction Figure 1 | The epigenetic landscape mediates the interplay."— Presentation transcript:

1 Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction
Figure 1 | The epigenetic landscape mediates the interplay between stressors and renal dysfunction. Both exogenous (environmental) and endogenous (physiological) stimuli lead to changes in the epigenetic landscape that impact renal ageing and physiology. These changes reflect accumulating allostatic load, both physiologically across the body and at the cellular and molecular levels. The resulting functional changes in cellular biology that reflect accelerated ageing processes in the organ act in concert with stress-driven physiological changes to induce further dysfunction that predisposes to and contributes to the progression of disease processes, which may further perturb all the tiers of the epigenome. lncRNA, long non-coding RNA; miRNA, microRNA; piRNA, piwi-interacting RNA; siRNA, small interfering RNA. Shiels, P. G. et al. (2017) The role of epigenetics in renal ageing Nat. Rev. Nephrol. doi: /nrneph

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