1. Figure 4 Activation of clopidogrel via cytochrome P450
Figure 4 | Activation of clopidogrel via cytochrome P450. a | Normal activation of clopidogrel occursvia CYP2C19. b | Loss-of-function mutation of CYP2C19 leads to reduced activation of clopidogrel. c | A possible reduced activation of clopidogrel has been suggested in patients on proton-pump inhibitor (PPI) therapy (particularly for omeprazole) due to competition for the same pathway.
Malfertheiner, P. et al. (2017) Proton-pump inhibitors: understanding the complications and risks
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro