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Development of Mock Circulatory System and Cardiovascular Parameters John Marshall Dr. Gerald Miller Charles Taylor VCU Biomedical Engineering.

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Presentation on theme: "Development of Mock Circulatory System and Cardiovascular Parameters John Marshall Dr. Gerald Miller Charles Taylor VCU Biomedical Engineering."— Presentation transcript:

1 Development of Mock Circulatory System and Cardiovascular Parameters John Marshall Dr. Gerald Miller Charles Taylor VCU Biomedical Engineering

2 Why is this important?! What is congestive heart failure? How many donor hearts are available each year? How many deaths per year? How much is it costing the U.S.? How many patients need a donor heart? Inadequate distribute of blood OVER 300,000 in the U.S.! Estimated less than 2,000! 100,000 need donor hearts $35 billion in the United States

3 Ventricular Assist Pumps (VADs) Bridge to recovery Bridge to transplantation Hows it help? Hows it work? pump blood through circulatory system restore the patients cardiac output waiting for a donor heart to become available allowing the heart muscle to rest and heal promote tissue and functional recovery

4 Testing Using the Mock Circulatory System Why is this important??? Food and Drug Administration Required before moving to animal and human trials $$$$ Why not go straight to animal trials? evaluate the hemodynamics refine VAD designs

5 Mock Circulatory System Harvard Pump Compliance Chamber Resistor Venous Reservoir LVAD Components Purpose?

6 Harvard Pump Why is it used? What can it do? What is being pumped? Harvard Pump Gold standard Pulsatile stroke volume Heart rate time in systole Blood analog40% glycerin, 60% water Mimics viscosity and density properties

7 Harvard Pump

8 Compliance Chamber Purpose? Compliance Chamber Pulse wave dampening Hows it work? mimics the elasticity of the arteries Dispersion force

9 Compliance Chamber

10 Resistor What does it do? How does it work? Resistor simulate peripheral resistance friction between the blood and the walls of blood vessels Motor compresses plates Adjust cross sectional circumference

11 Resistor

12 Venous Reservoir Purpose? Venous Reservoir Hows it work? Smooth delivery of liquid Pressure based on varying volume

13 Venous Reservoir

14 Multi-Disk Centrifugal Pump Design LVAD Advantages 5 disks 0.063in. thick 0.016in. spacing Connected to a DC motor Rocket fuel Smooth ejection High RPM generates high pressure

15 Multi-Disk Centrifugal Pump How does it operate? 1- Fluid enters rotor area 2- Fluid enters space between disks 3- Fluid is spun at high speeds 4- Fluid spins off disks into volute chamber 5- Fluid is ejected through outlet

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18 What are we trying to replicate? The human cardiovascular system Pulmonary circulation Systemic circulation Under what conditions? Rest Exercise Transitioning Pathological

19 Development of Cardiovascular Parameters How did I do this? Cardiovascular parameters Postural changes affecting blood pressure Cardiac output during exercise Mock circulatory system

20 What was I looking For?

21 Heart rate-Heart rate- beats per minute- (cardiac cycle/60x1000) ¯¹ Which parameters are necessary? Stroke volume-Stroke volume- amount of blood pump in one contraction- CO/HR*1000 Cardiac output-Cardiac output- volume of blood pumped per minute- HR * SV/1000 Systolic pressure-Systolic pressure- heart contracting Diastolic pressure-Diastolic pressure- heart relaxing Time is systole-Time is systole- % heart contraction- Ejection duration/cardiac cycle Peripheral resistance-Peripheral resistance- opposition encountered by blood flow- ( (MAP-CVP)* 80) / (CO)

22 Heart rate-Heart rate- beats per minute- (cardiac cycle/60x1000) ¯¹ Which parameters are necessary? Stroke volume-Stroke volume- amount of blood pump in one contraction- CO/HR*1000 Cardiac output-Cardiac output- volume of blood pumped per minute- HR * SV/1000 Systolic pressure-Systolic pressure- heart contracting Diastolic pressure-Diastolic pressure- heart relaxing Time is systole-Time is systole- % heart contraction- Ejection duration/cardiac cycle Peripheral resistance-Peripheral resistance- opposition encountered by blood flow- ( (MAP-CVP)* 80) / (CO)

23 Heart rate-Heart rate- beats per minute- (cardiac cycle/60x1000) ¯¹ Which parameters are necessary? Stroke volume-Stroke volume- amount of blood pump in one contraction- CO/HR*1000 Cardiac output-Cardiac output- volume of blood pumped per minute- HR * SV/1000 Systolic pressure-Systolic pressure- heart contracting Diastolic pressure-Diastolic pressure- heart relaxing Time is systole-Time is systole- % heart contraction- Ejection duration/cardiac cycle Peripheral resistance-Peripheral resistance- opposition encountered by blood flow- ( (MAP-CVP)* 80) / (CO)

24 Heart rate-Heart rate- beats per minute- (cardiac cycle/60x1000) ¯¹ Which parameters are necessary? Stroke volume-Stroke volume- amount of blood pump in one contraction- CO/HR*1000 Cardiac output-Cardiac output- volume of blood pumped per minute- HR * SV/1000 Systolic pressure-Systolic pressure- heart contracting Diastolic pressure-Diastolic pressure- heart relaxing Time is systole-Time is systole- % heart contraction- Ejection duration/cardiac cycle Peripheral resistance-Peripheral resistance- opposition encountered by blood flow- ( (MAP-CVP)* 80) / (CO)

25 Heart rate-Heart rate- beats per minute- (cardiac cycle/60x1000) ¯¹ Which parameters are necessary? Stroke volume-Stroke volume- amount of blood pump in one contraction- CO/HR*1000 Cardiac output-Cardiac output- volume of blood pumped per minute- HR * SV/1000 Systolic pressure-Systolic pressure- heart contracting Diastolic pressure-Diastolic pressure- heart relaxing Time is systole-Time is systole- % heart contraction- Ejection duration/cardiac cycle Peripheral resistance-Peripheral resistance- opposition encountered by blood flow- ( (MAP-CVP)* 80) / (CO)

26 Heart rate-Heart rate- beats per minute- (cardiac cycle/60x1000) ¯¹ Which parameters are necessary? Stroke volume-Stroke volume- amount of blood pump in one contraction- CO/HR*1000 Cardiac output-Cardiac output- volume of blood pumped per minute- HR * SV/1000 Systolic pressure-Systolic pressure- heart contracting Diastolic pressure-Diastolic pressure- heart relaxing Time is systole-Time is systole- % heart contraction- Ejection duration/cardiac cycle Peripheral resistance-Peripheral resistance- opposition encountered by blood flow- ( (MAP-CVP)* 80) / (CO)

27 Heart rate-Heart rate- beats per minute- (cardiac cycle/60x1000) ¯¹ Which parameters are necessary? Stroke volume-Stroke volume- amount of blood pump in one contraction- CO/HR*1000 Cardiac output-Cardiac output- volume of blood pumped per minute- HR * SV/1000 Systolic pressure-Systolic pressure- heart contracting Diastolic pressure-Diastolic pressure- heart relaxing Time is systole-Time is systole- % heart contraction- Ejection duration/cardiac cycle Peripheral resistance-Peripheral resistance- opposition encountered by blood flow- ( (MAP-CVP)* 80) / (CO)

28 Cardiovascular responses to postural changes: differences with age for women and men. T (s) HR (bpm) SV (ml/beat) MSER (mL x sec¯¹) CO(1 x min¯¹) SP (mm Hg) DP (mm Hg) Systole (%)Sex Postural Pos. Head Angle (Degrees)ConditionActivityVAD Mean AgePredecessorReference 130058.711837912077Malesupine0HealthyRestN21-590Frey MA. 230066.5822610870Femalesupine0HealthyRestN21-590Frey MA. 330065.98731412082Malesit90HealthyRestN21-591Frey MA. 4300706221211176Femalesit90HealthyRestN21-592Frey MA. 530072.37229611984Malestand90HealthyRestN21-593Frey MA. 630081.84819511078Femalestand90HealthyRestN21-594Frey MA. Cardiac output= (58.7 x 118)/ 1000 = 6.9 Cardiac output= (HR x SV)/ 1000

29 T (s) HR (bpm) SV (ml/beat) MSER (mL x sec¯¹) CO(1 x min¯¹) SP (mm Hg) DP (mm Hg) Systole (%)Sex Postural Pos. Head Angle (Degrees) Conditio n Activit yVAD Mean AgePredecessorReference 130058.71183796.912077Malesupine0HealthyRestN21-590Frey MA. 230066.582265.410870Femalesupine0HealthyRestN21-590Frey MA. 330065.9873145.712082Malesit90HealthyRestN21-591Frey MA. 430070622124.311176Femalesit90HealthyRestN21-592Frey MA. 530072.3722965.211984Male standin g90HealthyRestN21-593Frey MA. 630081.848195411078Female standin g90HealthyRestN21-594Frey MA. Time in systole= Ejection duration/cardiac cycle Mean Stroke Ejection Rate= Stroke Volume/ Ejection Duration Ejection Duration= Stroke Volume/ MSER Ejection Duration= 118/ 379= 0.311 Time in systole= (0.311/ 1) x 100 = 31.1%

30 Cardiovascular responses to postural changes: differences with age for women and men. T (s) HR (bpm) SV (ml/beat) MSER (mL x sec¯¹) CO(1 x min¯¹) SP (mm Hg) DP (mm Hg) Systole (%)Sex Postural Pos. Head Angle (Degrees) Conditio n Activit yVAD Mean AgePredecessorReference 130058.71183796.91207731.1Malesupine0HealthyRestN21-590Frey MA. 230066.582265.41087031.5Femalesupine0HealthyRestN21-590Frey MA. 330065.9873145.71208227.8Malesit90HealthyRestN21-591Frey MA. 430070622124.31117629.2Femalesit90HealthyRestN21-592Frey MA. 530072.3722965.21198424.3Male standin g90HealthyRestN21-593Frey MA. 630081.84819541107824.6Female standin g90HealthyRestN21-594Frey MA.

31 Physiological responses to postural change in young and old healthy individuals. T (s) HR (bpm) SV (ml/beat) CO (1 x min¯¹) SP (mm Hg) DP (mm Hg)Sex Postural Pos. Head Angle (Degrees)ConditionActivityVAD Mean AgePredecessorReference 730065.5114.87.45107.269.3BothSupine0HealthyRestN310Vargas E. 830080.179.76.18140.981.4BothSupine0HealthyRestN710Vargas E. 930083.562.55.11106.278.5BothSupine70HealthyRestN317Vargas E. 1030089.762.45.58139.492.2BothSupine70HealthyRestN718Vargas E. 1130063.8110.36.91104.570.1BothSupine0HealthyRestN319Vargas E. 1230076.772.75.41142.282.5BothSupine0HealthyRestN7110Vargas E.

32 A complete mock circulation loop for the evaluation of left, right, and biventricular assist devices. Time (s) Heart Rate (bpm) Stroke Volume (ml/beat) Cardiac Output (1 x min¯¹) Systolic Pressure (mm Hg) Diastolic Pressure (mm Hg) Systemic Venous Compliance (mL/mm Hg) Time in Systole (%) Left Atrial Pressure (mm Hg) 243006083.3351208022.5409 253006041.672.5705011.54020 Left Ventricle Pressure (mm Hg) Left Ventricle End Diastolic Pressure (mm Hg)Sex Postural Position Head Angle (Degrees) Pathological ConditionActivityVAD UsedMean AgeReference 0-1208N/A 0 HealthyRestNN/ATimms D. 15-8020N/A 0 HFRestNN/ATimms D.

33 Current status… Construction is incomplete Parameter spreadsheet is in progress Future… Run developed parameters in completed mock loop Confidence level

34 Thanks for a GREAT summer! Dr. Gerald Miller for his lab time and resources Charles Taylor for his time, patience, and guidance Dr. Jeff Elhai, Sherry Baldwin, and Andy Surface for directing BBSI National Science Foundation for the grant money!


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