1. Understanding the Many Faces of Pseudobulbar Affect

2. This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the United States.

3. What Is PBA?

4. Pathophysiology of PBA

5. Essential Criteria for PBA

6. Supportive Criteria for PBA

7. Differential Diagnosis of PBA

8. Prevalence of PBA Symptoms in Published Studies

9. Prevalence of PBA in PRISM

10. Impact of PBA on QoL According to Neurologic Condition

11. Decreased QoL in Veterans With TBI and PBA

12. STAR Trial Design

13. STAR Trial Results

14. PRISM II Design

15. PRISM II Results

16. PBA Recognition

17. PBA Recognition (cont)

18. Treatment Options

19. Treatment Considerations With DM/Q

20. Treatment Considerations With TCAs and SSRIs

21. Conclusions

22. Abbreviations