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Treatment of NAFLD with diet, physical activity and exercise

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Presentation on theme: "Treatment of NAFLD with diet, physical activity and exercise"— Presentation transcript:

1 Treatment of NAFLD with diet, physical activity and exercise
Manuel Romero-Gómez, Shira Zelber-Sagi, Michael Trenell  Journal of Hepatology  Volume 67, Issue 4, Pages (October 2017) DOI: /j.jhep Copyright © 2017 European Association for the Study of the Liver Terms and Conditions

2 Fig. 1 A summary of the nutritional treatment options (based on clinical trials or observational studies) through the course of NAFLD. Remission of steatosis can occur with weight reduction achieved by several types of diet or with isocaloric Mediterranean diet (which induces metabolic and anti-inflammatory benefits), as indicated by clinical trials. For remission of NASH or fibrosis, there is no evidence from clinical trials for a benefit of merely improving dietary composition, while there is evidence that at least 7% weight reduction is needed. For prevention of progression to liver cancer, the evidence regarding certain foods and nutrients is derived only from large observational studies and needs further confirmation. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2017 European Association for the Study of the Liver Terms and Conditions

3 Fig. 2 Benefits of exercise and physical activity in NAFLD: changes in the liver and changes to cardiovascular system. EDV, end diastolic volume; SV, stroke volume; EF, ejection fraction; FMD, flow-modulated dilatation; VLDL, very low density lipoprotein. Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2017 European Association for the Study of the Liver Terms and Conditions

4 Fig. 3 Probability of reaching NASH resolution, fibrosis regression (at least one stage) and steatosis improvement in patients with NASH under lifestyle intervention according to percentage of weight loss (modified from Vilar-Gomez et al.12). Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2017 European Association for the Study of the Liver Terms and Conditions

5 Fig. 4 A practical guide for behavioural therapy in the lifestyle treatment of NASH.171 Journal of Hepatology  , DOI: ( /j.jhep ) Copyright © 2017 European Association for the Study of the Liver Terms and Conditions


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