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Immunology of Renal Transplant Ahmad Jaber ALMUJALHEM-K.U.B. R III-Academic Day 30 th Jan 2014.

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Presentation on theme: "Immunology of Renal Transplant Ahmad Jaber ALMUJALHEM-K.U.B. R III-Academic Day 30 th Jan 2014."— Presentation transcript:

1 Immunology of Renal Transplant Ahmad Jaber ALMUJALHEM-K.U.B. R III-Academic Day 30 th Jan 2014

2 Outline Immunology in Urology Selection & Preparation of kidney transplant: Recipient Donor RENAL ALLOGRAFT REJECTION Classification of Rejection

3 Immunology in Urology Immunocompromised patient Auto Immune diseases Wound healing and Immune system Neoplasm and Immune system Infection and Immune system Infertility and Immune system Vaccine Immunotherapy Immunosuppressant

4 Facts!

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6 SELECTION AND PREPARATION OF KIDNEY TRANSPLANT RECIPIENTS Preliminary Screening Next…

7 Recipient Next…

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10 Donor Next…

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14 RENAL ALLOGRAFT REJECTION Next…

15 Histocompatibility ABO blood group Major histocompatibility complex (MHC): Class I antigens: HLA-A, HLA-B & HLA-C T lymphocytes Class II antigens: HLA-DR,HLA-DQ, HLA-DP B lymphocytes, activated T lymphocytes, monocytes, macrophages,dendritic cells &some endothelial cells

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18 Classification of Rejection Hyperacute rejection: Immediately after renal revascularization Irreversible process Mediated by preformed circulating cytotoxic antibodies Accelerated rejection: Mediated by humoral and cellular components Within days to weeks Does not respond to antirejection therapy. Acute rejection (any time after transplantation) Chronic rejection: Gradual decline in renal function Interstitial fibrosis Vascular changes Minimal mononuclear cell infiltration

19 mediated-rejection-post-kidney-transplantation

20 Nature Reviews Nephrology 8, (November 2012) | doi: /nrneph

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22 symptoms of acute kidney transplant rejection the flu accompanied by pain Enlarged kidney graft Hypertension Decreased urinary output Fluid retention Increased serum creatinine levels

23 Dx Needle biopsy of the kidney graft is the standard to confirm the diagnosis of acute rejection. Typical histologic findings of acute renal allograft rejection: Mononuclear cellular infiltration Tubulitis Vasculitis

24 Immunosuppression

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27 Reports/Pages/Betterdrugsprolongkidneytransplantpatients'lives(SingaporeHealthIssue,May-June2013,Pg5).aspx

28 Thanks Question Discussion


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