1. Neonatal GATA1 mutant clones under the radar
by Jeffrey W. Taub
Blood
Volume 122(24):
December 5, 2013
©2013 by American Society of Hematology

2. (1) Abnormal fetal myeloid progenitor department, where GATA1 mutant clones arise in the fetal liver; (2) 200 Down syndrome neonates are screened; (3) 195/200 (97.5%) have circulating blasts; (4) Sanger sequencing/denaturing high-performance liquid chromato...
(1) Abnormal fetal myeloid progenitor department, where GATA1 mutant clones arise in the fetal liver; (2) 200 Down syndrome neonates are screened; (3) 195/200 (97.5%) have circulating blasts; (4) Sanger sequencing/denaturing high-performance liquid chromatography detects mutant GATA1 clones in 17/200 (8.5%) patients (TAM); (5) next-generation sequencing detects mutant GATA1 clones in 18/88 (20.4%) patients (“silent TAM”); (6) myeloid leukemia of Down syndrome develops in 3 TAM patients and 1 silent TAM patient. Professional illustration by Marie Dauenheimer.
Jeffrey W. Taub Blood 2013;122:
©2013 by American Society of Hematology