1. Optimizing Therapy for Osteoarthritis

2. Introduction Osteoarthritis

3. 2012 ACR Pharmacologic Recommendations for Initial Management of Knee OA

4. 2012 ACR Pharmacologic Recommendations for Initial Management of Hip OA

5. Facing an Opioid Epidemic and the Implications for Changes in Treatment Landscapes

6. Patient Case

7. Patient Assessment and Initial Treatment

8. Patient Case 5 Years Later

9. Patient Case Re-Evaluation

10. Lack of Paracetamol (Acetaminophen) Efficacy

11. Oral NSAID Use and Selection Important Considerations

12. Assessment for NSAID GI Toxicity Risk 2009 ACG Guidelines

13. Oral NSAID Use And Cardiotoxicity

14. Variables Determining NSAID CV Risk

15. Selection of NSAIDs

16. PRECISION Trial Design

17. PRECISION Trial Findings

18. Limitations of PRECISION

19. Patient Case (cont)

20. Effect of Opioid vs Non-Opioid Medications on Pain-Related Function

21. Abbreviations