1. What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies
by Wendy Stock, Mei La, Ben Sanford, Clara D. Bloomfield, James W. Vardiman, Paul Gaynon, Richard A. Larson, and James Nachman
Blood
Volume 112(5):
September 1, 2008
©2008 by American Society of Hematology

2. Comparison of EFS and OS
Comparison of EFS and OS. (A) Comparison of EFS among CALGB (gray line) and CCG (black line) patients.
Comparison of EFS and OS. (A) Comparison of EFS among CALGB (gray line) and CCG (black line) patients. The 7-year RHR for CALGB patients was 2.2 (CI, ; P < .001). (B) Comparison of OS among CALGB (gray line) and CCG (black line) patients. The 7-year relative hazard ratio (RHR) for death in CALGB patients was 1.9 (CI, ; P < .001).
Wendy Stock et al. Blood 2008;112:
©2008 by American Society of Hematology

3. Estimated incidence of isolated CNS relapses.
Estimated incidence of isolated CNS relapses. The 7-year estimated incidence of isolated CNS relapses (ICNS) of 11% for CALGB patients (9 events) was significantly higher than the ICNS rate of 1.4% (2 events) for CCG patients (P < .001); RIR, 9.2 (CI, ).
Wendy Stock et al. Blood 2008;112:
©2008 by American Society of Hematology

4. Age effect on outcome.
Age effect on outcome. CALGB patients aged 16 to 17 years had a 7-year EFS of 55%, which was similar to a 64% EFS for 16- to 17-year-old CCG patients (P = .49). CALGB patients aged 18 to 20 years old had a 7-year EFS of 29%, which was significantly worse than that for the younger CALGB patients and the 57% EFS for 18- to 20-year-olds on CCG trials (P = .01; RHR, 2.1 [CI, ]).
Wendy Stock et al. Blood 2008;112:
©2008 by American Society of Hematology