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Physical Pharmacy 2 1 KAUSAR AHMAD KULLIYYAH OF PHARMACY, IIUM PROPERTIES OF POLYMERS.

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Presentation on theme: "Physical Pharmacy 2 1 KAUSAR AHMAD KULLIYYAH OF PHARMACY, IIUM PROPERTIES OF POLYMERS."— Presentation transcript:

1 Physical Pharmacy 2 1 KAUSAR AHMAD KULLIYYAH OF PHARMACY, IIUM PROPERTIES OF POLYMERS

2 CONTENTS 1.Polymerisation factors 2.Tg, Tm 3.Tensile strength 4.Diffusion coefficient 5.Permeability Physical Pharmacy 2 2

3 TOP MONOMERS Physical Pharmacy 2 3

4 TOP POLYMERS IN PHARMACEUTICALS? Physical Pharmacy 2 4 TypeApplicationProperties Submit through LMS

5 TYPES OF POLYMERS Physical Pharmacy 2 5

6 REACTION MECHANISMS Addition-> Chain-growth By free radical or ion e.g. polyethylene polypropylene polystyrene Condensation-> Step-growth By functional groups e.g. polyurethane polyester naturally occurring polymers Physical Pharmacy 2 6

7 POLYMERISATION CONDITIONS Physical Pharmacy 2 7

8 DEGREE OF POLYMERIZATION (n)- the number of monomer units that have polymerized together. D.P. values can be as high as 10,000. Exercise: What are the factors that influence D.P.? Physical Pharmacy 2 8 Submit through LMS

9 PHYSICAL PROPERTIES Physical Pharmacy 2 9

10 PHYSICAL AND MECHANICAL PROPERTIES Physical Pharmacy 2 10

11 POLYMER CRYSTALLINITY Physical Pharmacy 2 11

12 TENSILE STRENGTH Physical Pharmacy 2 12

13 Physical Pharmacy 2 13 strain stress A B C D [A] Stress at the Yield Point: At this point the force of the tensile pull is sufficient to cause polymer chains to slip past each other, and yield occurs. [B] Elongation at the Yield Point: Maximum stretching before yield failure takes place [C] Stress at Failure: At this level of stress the polymer molecules can no longer maintain cohesive integrity and the sample breaks [D] Elongation at Failure: This is how much the sample can stretch before it breaks

14 DIFFUSION IN A POLYMER Physical Pharmacy 2 14

15 FACTORS INFLUENCING DIFFUSION COEFFICIENT Physical Pharmacy 2 15

16 PERMEABILITY Physical Pharmacy 2 16

17 NATURAL PERMEABILITY OF POLYMERS Physical Pharmacy 2 17

18 POLYMER FILM PREPARATION Physical Pharmacy 2 18

19 PHASE SEPARATION IN POLYMER FILMS Physical Pharmacy 2 19

20 REFERENCES Aulton, M. E. (1988). Pharmaceutics: The Science of dosage form design. London: Churchill Livingstone. Wise, D. L. (2000). Handbook of Pharmaceutical Controlled Release Technology. New York: Marcel Dekker. Chasin, M & Langer, R (1990). Biodegradable polymers as drug delivery systems. New York: Marcel Dekker. Vyas, S. P & Khar, R. K. (2002). Targeted and controlled drug delivery. New Delhi: CBS. Physical Pharmacy 2 20


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