1. Microscopic appearance of skin wounds in mock‐ and galardin‐treated Plg‐deficient and wild‐type mice.
Microscopic appearance of skin wounds in mock‐ and galardin‐treated Plg‐deficient and wild‐type mice. Sections of skin wounds 7 days after surgery were stained with Masson‐trichrome. In mock‐treated (a and b) and galardin‐treated (c and d) wild‐type mice, the epidermal tongue is wedge shaped and surrounded by a loose network of extracellular matrix. In mock‐treated (e and f) and galardin‐treated (g and h) Plg‐deficient mice, the epidermal ends are blunted and surrounded by a dense layer of fibrillar material. The fibrillar material is shown by curved arrows in (e–h) and is most pronounced in the galardin‐treated Plg‐deficient mice (h). In (a), (c), (e) and (g), the straight closed arrows indicate the tip of the epidermal tongue and the straight open arrows indicate the point at the start of the zone of proliferating keratinocytes used for measurements of the length of the epidermal tongue. (b), (d), (f) and (h) are larger magnifications of (a), (c), (e) and (g), respectively. Magnification: (a), (c), (e) and (g), ×45; (b), (d), (f) and (h), ×90.
Leif R. Lund et al. EMBO J. 1999;18:
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