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The ART of Lowering Ceramides

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1 The ART of Lowering Ceramides
Scott A. Summers  Cell Metabolism  Volume 22, Issue 2, Pages (August 2015) DOI: /j.cmet Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic Depicting the Effect of Adipose and Liver Ceramidase Activation on Metabolic Homeostasis Xia and colleagues (Xia et al., 2015) studied new mouse models allowing for the acute induction of acid ceramidase in liver and adipose tissue. Increasing rates of ceramide deacylation in either location markedly improved the metabolic health of both tissues, revealing new roles for sphingolipids in liver-fat crosstalk. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2015 Elsevier Inc. Terms and Conditions


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