1. Effect of intervention on diastolic function.
Effect of intervention on diastolic function. A and B, Change in individual stiffness constants from the diastolic portion of the LV diastolic pressure-volume relationships and LV diastolic transmural pressure-volume relationship, respectively. Modeling was performed for each individual participant, at baseline and repeated after 2 years. C and D, The group mean LV diastolic pressure-volume and LV diastolic transmural pressure-volume relationships before and after 2 years of intervention. In the ExT group, both the LV pressure-volume and transmural curves were shifted rightward with a flattening slope demonstrating improved LV compliance and distensibility. The control group was unchanged. *P<0.05 denotes significantly different from pre. ExT indicates exercise training; LVEDVi, left ventricular end-diastolic volume index; PCWP, pulmonary capillary wedge pressure; and TMP, transmural pressure.
Erin J. Howden et al. Circulation. 2018;137:
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