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Presentation on theme: "ADVANCED TECHNOLOGY IN BLOOD SEPARATION Lmb Technologie GmbH."— Presentation transcript:


2 ErySep ! Unique and New Blood Separation Technology Blood Separation without mechanical devices »Without Centrifuge »Without Separation Press »Without Power Supply Blood Separation by gravity force »ErySep separates whole blood into two components ( RED CELL and PLASMA ) by itself without any other instruments Separated Blood Components in perfect quality »Cells Free PLASMA »Leukocyte Free RED CELL »Concentrated RED CELL ( 55%-60% HTC )

3 ErySep ! Unique and New Blood Separation Technology Approved Clinical Results »Studying on different parameters such as; pH, LDH, K, P, NH3, Osmolality, 2,3-DPG, Total protein, Hemoglobin in TU (g/unit), Loss of Hb, Haemolysis, Leucocytes, F VIII activity, Platelets, the results have been published in international scientific magazines. Validation in different Country Blood Banks German Blood Banks Indonesia Blood Banks UK Blood Banks Malaysia Blood Banks Spain Blood BanksMyanmar Blood Banks Bulgaria Blood BanksTaiwan Blood Banks Greece Blood Banks Philippines Blood Banks Chech Blood BanksEgypt Blood Banks Slovakia Blood BanksYemen Blood Banks Belgium Blood BanksJordan Blood Banks Turkish Blood BanksSaudi Blood Banks Russia Blood Banks All results meets with European Blood Components Standard Guide to the preparation, use and quality assurance of blood components - 15th Edition (2009)Guide to the preparation, use and quality assurance of blood components - 15th Edition (2009)

4 ErySep ! Unique and New Blood Separation Technology WHY ERYSEP? ErySep is user friendly No necessary special education Work in all kind of environment (outdoor/indoor) It is activated in 5 minute, and no need extra efforts Staff can do their other daily work ErySep complete process by itself within 75 minutes. ErySep is a Closed Sterile System It can not effect outside conditions Cost Reduction No centrifuge & extractor investment No maintainance cost in routine usage No power supply Easy Handling 24 month shelflife in room condition Easy Product exchange & replacement Portable & ready work wherever needed Ready to use any time for any amount Expert can obtain specific demanded quantity ErySep can answer night time demand

5 ErySep ! Unique and New Blood Separation Technology ErySep® is a disposable system has standard triple blood bag whole blood bag red cell bag plasma bag with an integrated air drainage bag has standard leukocyte filter has test bag with vacu-container port has membrane filter embedded into separation chamber unit

6 ErySep ! Unique and New Blood Separation Technology HOW ErySep® WORKS? Donor Blood is taken into Mother bag by using an integrated needle on the system. ErySep works by gravity force, does not need any other instruments or power supply. System can activate just by breaking internal plastic valves, after hanging to a infusion stand. Tubular membrane with a diameter of <1 mm and hollows (pores) 0,2 µm make physical separation; Red Cells are pushed into Red Cell Bag, Plasma are pushed into Plasma Bag through the membrane filter.

7 ErySep ! Unique and New Blood Separation Technology Medical ADVANTAGES of ErySep® ErySep supplies Leuko-depleted Red Cell & Plasma Erysep supplies high HTC level into the Packed Red Cell Bag. ErySep supplies plasma, which is ready for FFP ErySep supplies Packed Red Cell Bag, which can be store 42 days. Leuko-depleted components are precious for Oncology and Hematology Patients Make available the fresh components at hospital for surgical operation purposes. Make available the fresh components for the patients need routine transfusion at hinterland.

8 TimeDay 0Day 42 pH Average value LDH (µkat/l) Average value K (mmol/l) Average value P (mmol/l) Average value NH3 (µmol/l) Average value Osmolality (mOsm/l) Average value ATP (µmol/g Hb) Average value DPG (µmol/g Hb) Average value Hemolysis Average value Datas from Hospital Prag Dr. Bohaniek

9 Rating and Validation of ErySepe..aıood donation and Blood separation device Dr. med.Dr.rer.nat Kurt Mannemann-Pohl Germany – Hamburg - Pohl Fachaat fOr Laboratoriumsmedizin Facharzt fOr Transfusionsmedizin DipL. Chem. BACKGROUND: ErySep Blood Donation and Blood separation device has been validated in Hamburg at Marien Krankenhaus Blood bank. Whole results have been reported as clinical study. STUDY DESIGN AND METHODS: The used analysis methods performed in the laboratory of the Marienkrankenhaus Hamburg and are listed below. All analysers and reagents were CE certified. All analysis methods were under permanent supervision of our quality control system with permant internal and four external controls per year.

10 RBC Results German Studies ( n=15 ) Value Avarage volume unit346 ml Hb17,4 g/dl Haematocrit54% Leucocytes in unit on day 10,03x10 6 Protein / unit3,3 g/unit K + in RBC on day 10,28mmol/l Free Hb on day 1all<0,03 g/l Free Hb on day 421,5 g/l Units were sterile as tested with BacT/Alert Culture System of BioMerieux Plasma Results German Studies ( n=15 ) Plasma volume232 ml Protein concentration53,5 g/l Leukocytes per unit0,02 WBC/unit Fibrinogen191 mg/dl ATIII82% of normal vWF-antigen82% of normal F VIII82% of normal Units were sterile as tested with BacT/Alert Culture System of BioMerieux

11 CONCLUSION: Easy to perform blood separation without the need for centrifuge, separator or even electricity; For donor and patient the procedure do not change; Plasma has a very good quality and is better than the standard blood bank quality; RBCs are better compared to standard blood bank quality. Remarkable is the very low WBC contect of far less than 1 WBC/µl ( effect of the hollow fibres ); Variation of measured parameters were all within the accepted limits for blood bank routine. The ErySep-Device is a ready to use blood donation and separation system. It is allowing, to produce leukocyte depleted erythrocyte concentrate and a cell free plasma with an elegant and save procedure with less equipment and limited manpower. In one of the last validations of ErySep ( ). we can say, that the results of the related labor tests are identical with the standards of the European Guidelines. The ErySep is separating the donor blood only by earth gravitation, without electricity or using of centrifuges etc.

12 Cord Blood separation for obtaining fetal erithrocytes.Preliminar results. / December Marta Torrabadella Spain / Cord Blood Bank. Banc de Sang i Teixits. Barcelona BACKGROUND: Cord blood separation with membrane filter technology is totally new and available in 2009 commercially. The first clinical study made by Dr Brune in Germany. This is 2nd study, which was perfomed in December STUDY DESIGN AND METHODS: The aim of the study is to show characterization of cord blood components after separation with ErySep system. ErySep system offers the possibility of blood separation of plasma and erythrocyte concentrate by gravity

13 RBC concentration ValueRange Mean fetal Hb67,8%76- 58,6 Median Hb obtained in RBC concentrate5,51,8-10,6 Percentage hemolysis0,26% 0,13 – 0,48 LDH (U/L) : Basal (n= 3 ) K+ (mmol/l) : Basal (n= 3)1,63 1,54 - 1,76 Plasma ValueRange Plasma Volume (ml) (n= 11) Platelet concentration (CellDyn) in Plasma (n= 13) Protein (g/L) in Plasma (n= 12)2,452- 3,3 K+ mmol/l in Plasma (n= 7)4,383,13- 5,96 LDH (UI) in Plasma (n= 7)370, Free Hb (n= 12)0.0220,00- 0,06 WBC/µL (n= 13)


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