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Expression der Östrogenrezeptoren (ER) alpha und beta

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Metavectum Recklinghausen Modern Moleculare Diagnostic in Oncology.

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Presentation on theme: "Expression der Östrogenrezeptoren (ER) alpha und beta"— Presentation transcript:

1 Expression der Östrogenrezeptoren (ER) alpha und beta
Normale Zellen Tumorzellen Tumorzellen mit Soja-Extrakt Brust / Ovar Prostata unbehandelt konstantes Verhältnis Anstieg Absinken ß Anstieg Absinken a HEALTHY PEOPLE HAVE MORE ESTROGEN BETA RECEPTORS (ER-B) THAN ER-ALPHA (ER-A) a ß ß a ER-beta ER-beta ER-alpha ER-alpha ER-beta ER-alpha

2 Estrogen-receptor beta is induced by Haelan 951
PROSTATE CELLS

3 Estrogenreceptor-beta (ER-beta) Expression
= No Haelan951 = Haelan951 application 33,9 Mamma-Ca. Patients with Haelan951 Healthy persones without Haelan951 Relative Genexpression ER-BETA INCREASED IN PATIENTS CONSUMING HAELAN 951 6,2 Healthy persones n= Mamma-Ca. patients n=5

4 Estrogen-receptor beta is induced by Haelan 951
ESTROGEN RECEPTOR BETA (ER-B) INCREASED IN OVARIAN CANCER PATIENTS

5 Stoffwechselweg der Apoptose
Duales Signal von c-myc: Der apoptotische Stoffwechselweg wird blockiert durch bcl2 / bax und c-myc fördert Proliferation Nach Verlust des bcl2 Überlebenssignals, fördert c-myc die Apoptose c - myc mitogens proliferation apoptosis Bcl2 (survival signals) blocking NF kB Bax PRO-APOPTIC CONDITIONS FACTORS INFLUENCING RESTORATION OF NORMAL CELL DEATH

6 Apoptotic conditioning induced by Healan 951
CTCs of prostate cancer patients showed an increased gene expression ratio of apoptosis-triggering genes bax/bcl2 after Haelan951-therapy HAELAN 951 INCREASES RATION BETWEEN BAX AND BCL2


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