1. Volume 70, Issue 5, Pages 829-836 (November 2016)
Simultaneous 68Ga-PSMA HBED-CC PET/MRI Improves the Localization of Primary Prostate Cancer 
Matthias Eiber, Gregor Weirich, Konstantin Holzapfel, Michael Souvatzoglou, Bernhard Haller, Isabel Rauscher, Ambros J. Beer, Hans- Jürgen Wester, Juergen Gschwend, Markus Schwaiger, Tobias Maurer 
European Urology 
Volume 70, Issue 5, Pages (November 2016)
DOI: /j.eururo
Copyright © 2016 European Association of Urology Terms and Conditions

2. Fig. 1
A 65-year-old patient with a biopsy-proven prostate cancer Gleason score of 6 and a prostate-specific antigen of 24.5 ng/ml. (A) Transverse T2-weighted images show considerable benign prostatic hyperplasia in the central zone presenting with one large and multiple surrounding small nodules. Prostate Imaging Reporting and Data System (PI-RADS) scoring using information from diffusion-weighted imaging (apparent diffusion coefficient map shown in B) and dynamic contrast-enhanced (enhancement curve in C) resulted in a PI-RADS scores of 2 for the right and left midgland sextants. Positron emission tomography (PET) and fused T2-weighted/PET images show intense focal uptake projecting on the right peripheral zone. Note that only slight diffuse uptake is present in the central gland. (D) In PET a score of 5 was given. (E) In the combined PET/magnetic resonance imaging (MRI), due to missing clearly suspicious findings on MRI, a score of 4 was given for the right midgland sextant. (F) Hematoxylin and eosin gross section histopathology shows an oval Gleason score 6 tumor focus in the right peripheral zone. Note that the different anteroposterior positive focus of the tumor nodus in imaging and histopathology is related to slightly different planes.
European Urology  , DOI: ( /j.eururo )
Copyright © 2016 European Association of Urology Terms and Conditions

3. Fig. 2
A 67-year-old patient with a biopsy-proven prostate cancer Gleason score of 7a and a prostate-specific antigen of 5.4 ng/ml. (A, B) Transverse T2-weighted images of apical sextants show slightly hypointense signal with restricted diffusion in the apparent diffusion coefficient map but isointense impression in the b-value 800 s/mm2 in the transitional zone. (C) Dynamic contrast-enhanced curve exhibits pronounced enhancement with a type 2 curve pattern resulting in a Prostate Imaging Reporting and Data System score of 3. (D) Positron emission tomography (PET) and (E) fused T2-weighted/PET images show intense focal uptake projecting ventrally to the urethra. Due to the high intensity of gallium 68 (68Ga)-prostate-specific membrane antigen (PSMA) HBED-CC uptake both in PET and 68Ga-PSMA HBED-CC PET/MRI, a score of 5 was applied. (F) Hematoxylin and eosin gross section histopathology shows a corresponding tumor focus.
European Urology  , DOI: ( /j.eururo )
Copyright © 2016 European Association of Urology Terms and Conditions

4. Fig. 3
Receiver operating characteristic curves for multiparametric magnetic resonance imaging (mpMRI), positron emission tomography (PET), and gallium 68 (68Ga)-prostate-specific membrane antigen (PSMA) HBED-CC PET/MRI on a sextant-based analysis.
European Urology  , DOI: ( /j.eururo )
Copyright © 2016 European Association of Urology Terms and Conditions

5. European Urology 2016 70, 829-836DOI: (10.1016/j.eururo.2015.12.053)
Copyright © 2016 European Association of Urology Terms and Conditions

6. European Urology 2016 70, 829-836DOI: (10.1016/j.eururo.2015.12.053)
Copyright © 2016 European Association of Urology Terms and Conditions

7. European Urology 2016 70, 829-836DOI: (10.1016/j.eururo.2015.12.053)
Copyright © 2016 European Association of Urology Terms and Conditions

8. European Urology 2016 70, 829-836DOI: (10.1016/j.eururo.2015.12.053)
Copyright © 2016 European Association of Urology Terms and Conditions

9. European Urology 2016 70, 829-836DOI: (10.1016/j.eururo.2015.12.053)
Copyright © 2016 European Association of Urology Terms and Conditions