Presentation on theme: "Heme-Onc presentation"— Presentation transcript:
1Heme-Onc presentation Dr. Prudhvi KarumanchiDr. Sohail Chaudhry
2Small Cell Lung cancer 51 y/o wf Presented with tingling and numbness in all her fingersDiagnosed with carpal tunnel syndrome and sent home.3 months later, pt developed asthmatic bronchitis with productive cough accompanied by mild hemoptysis.She also began to have difficulty finding words and remembering names of family members.
4Small Cell Lung CancerCT: Hilar mass with mediastinal lymphadenopathy.
5Small Cell Lung Cancer Bronchoscopy: Fine needle aspiration Diffuse mucosal infiltrationThickening of main and upper lobe bronchi on right side with small mucosal nodulesCytology was negative.Fine needle aspirationUndifferentiated small-cell carcinomaPt was treated with cisplatin and etoposide.
6EpidemiologySmall cell lung cancer accounts for 20-25% of all bronchogenic carcinomas.Strong correlation with smoking.Known genetic abnormality:Deletions in chromosome 3
8Small Cell Lung Cancer Symptoms and Signs: Central or endobronchial growth:CoughHemoptysisWheezeStridorPost-obstructive pneumonitisPeripheral Growth:DyspneaLung abscessRegional spread of tumor:Tracheal obstructionEsophageal compression with dysphagiaRec. laryngeal nerve paralysis with hoarsenessSympathetic nerve paralysis with horner’sSuperior vena cava syndrome with vascular obstruction